Role of miR-181 family in regulating vascular inflammation and immunity

被引:156
作者
Sun, Xinghui [1 ]
Sit, Alan [1 ]
Feinberg, Mark W. [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Cardiovasc Div, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
NF-KAPPA-B; CORONARY-ARTERY-DISEASE; T-CELL DEVELOPMENT; ANGIOTENSIN-II; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SEPTIC SHOCK; MICRORNAS; ATHEROSCLEROSIS; EXPRESSION;
D O I
10.1016/j.tcm.2013.09.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-kappa B signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:105 / 112
页数:8
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