C-3β-Tethered Functional Cholesterol Conjugates by Nitrile Oxide Alkyne Cycloaddition (NOAC)

被引：3

作者：

Algay, Virginie ^{[1
]}

O'Sullivan, Justine ^{[1
]}

Heaney, Frances ^{[1
]}

机构：

[1] Natl Univ Ireland, Dept Chem, Maynooth, Kildare, Ireland

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 12期

基金：

爱尔兰科学基金会;

关键词：

Steroids; Lipids; Cycloaddition; Alkynes; Heterocycles; Conjugation; COPPER(I)-CATALYZED SYNTHESIS; EFFICIENT SYNTHESIS; CLICK CHEMISTRY; DELIVERY; DERIVATIVES; STEROIDS; ETHERS; CHAINS; METAL;

D O I：

10.1002/ejoc.201301822

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Covalent cholesterol conjugates have been prepared by isoxazole-generating [3+2] nitrile oxide alkyne cycloaddition (NOAC) chemistry. Steroidal building blocks functionalised with either an alkyne or a nitrile oxide precursor were evaluated. The reaction has been demonstrated for the tethering to cholesterol of groups capable of bioreporting, and for the formation of cholesterol-biomolecule conjugates.

引用

页码：2522 / 2532

页数：11

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