Bispecific antibody platforms for cancer immunotherapy

被引：65
作者：
Lameris, Roeland [1 ]
de Bruin, Renee C. G. [1 ]
Schneiders, Famke L. [1 ]
Henegouwen, Paul M. P. van Bergen en [2 ]
Verheul, Henk M. W. [1 ]
de Gruijl, Tanja D. [1 ]
van der Vliet, Hans J. [1 ]
机构：
[1] Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands
[2] Univ Utrecht, Fac Sci, Dept Biol, Div Cell Biol, NL-3584 CH Utrecht, Netherlands
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2014年 / 92卷 / 03期
关键词：
Bi-specific antibodies; Dual specific retargeting; Immune effector cells; Anti-cancer therapy; NATURAL-KILLER-CELLS; DELTA T-CELLS; SINGLE-CHAIN ANTIBODY; EPCAM X ANTI-CD3; ACUTE LYMPHOBLASTIC-LEUKEMIA; EXPRESSING TUMOR-CELLS; NKT CELLS; MALIGNANT ASCITES; ANTITUMOR-ACTIVITY; PROSTATE-CANCER;
D O I：
10.1016/j.critrevonc.2014.08.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Over the past decades advances in bioengineering and expanded insight in tumor immunology have resulted in the emergence of novel bispecific antibody (bsAb) constructs that are capable of redirecting immune effector cells to the tumor microenvironment. (Pre-) clinical studies of various bsAb constructs have shown impressive results in terms of immune effector cell retargeting, target dependent activation and the induction of anti-tumor responses. This review summarizes recent advances in the field of bsAb-therapy and limitations that were encountered. Furthermore, we will discuss potential future developments that can be expected to take the bsAb approach successfully forward. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：153 / 165
页数：13
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