Enzyme reactions and genes in aflatoxin biosynthesis

被引：193

作者：

Yabe, K ^{[1
]}

Nakajima, H

机构：

[1] Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan

[2] Tottori Univ, Fac Agr, Tottori 6808553, Japan

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2004年 / 64卷 / 06期

关键词：

D O I：

10.1007/s00253-004-1566-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aflatoxins are highly toxic and carcinogenic substances mainly produced by Aspergillus flavus and Aspergillus parasiticus. Sterigmatocystin is a penultimate precursor of aflatoxins and also a toxic and carcinogenic substance produced by many species, including Aspergillus nidulans. Recently, the majority of the enzyme reactions involved in aflatoxin/sterigmatocystin biosynthesis have been clarified, and the genes encoding the enzymes have been isolated. Most of the genes constitute a large gene cluster in the fungal genome, and their expression is mostly regulated by a product of the regulatory gene aflR. This review will summarize the enzymatic steps and the genes in aflatoxin/sterigmatocystin biosynthesis.

引用

页码：745 / 755

页数：11

共 86 条

[1]

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