Molecular Profiling of Breast Cancer

被引：15
作者：
Cyr, Amy E. [1 ]
Margenthaler, Julie A. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 23卷 / 03期
关键词：
Breast cancer; Molecular profiling; Molecular diagnostics; Prognostication; Genome; 21-GENE RECURRENCE SCORE; CARCINOMA IN-SITU; EXPRESSION-BASED PREDICTORS; GENE-EXPRESSION; ONCOTYPE DX; DISTANT RECURRENCE; CLINICAL UTILITY; TOTAL MASTECTOMY; BASAL-LIKE; FOLLOW-UP;
D O I：
10.1016/j.soc.2014.03.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is now considered a heterogeneous and phenotypically diverse disease. Molecular profiling is used in clinical practice in 2 broad categories: (1) characterization of breast cancers beyond the standard histopathologic features such as tumor grade, histologic subtype, and biomarker profile for prognostic information; and (2) prediction of response to therapy and clinical outcome. This article addresses the importance and application of molecular subtype analysis, and provides an in-depth analysis of the clinical application of the molecular prognostic indices for ductal carcinoma in situ, node-negative invasive breast cancer, and node-positive invasive breast cancer.
引用
收藏
页码：451 / +
页数：14
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