Regulation of ovulation rate in mammals: contribution of sheep genetic models

被引：169
作者：
Fabre, Stephane [1 ]
Pierre, Alice
Mulsant, Philippe
Bodin, Loys
Di Pasquale, Elisa
Persani, Luca
Monget, Philippe
Monniaux, Danielle
机构：
[1] Univ Tours Haras Nationaux, CNRS, UMR 6175, INRA, F-37380 Nouzilly, France
[2] INRA, Lab Genet Cellulaire, F-31326 Castanet Tolosan, France
[3] INRA, Stn Ameliorat Genet Anim, F-31326 Castanet Tolosan, France
[4] Univ Milan, Inst Endocrine Sci, Ist Auxol Italiano, IRCCS, I-20095 Cusano Milanino, MI, Italy
来源：
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2006年 / 4卷 / 1期
关键词：
D O I：
10.1186/1477-7827-4-20
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate.
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页数：12
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