Synthesis and Self-Assembly of pH-Responsive Amphiphilic Poly(dimethylaminoethyl methacrylate)-block-Poly(pentafluorostyrene) Block Copolymer in Aqueous Solution

被引：27

作者：

Tan, Beng H. ^{[1
]}

Gudipati, Chakravarthy S. ^{[1
]}

Hussain, Hazrat ^{[1
]}

He, Chaobin ^{[1
]}

Liu, Ye ^{[1
]}

Davis, Thomas P. ^{[1
,2
]}

机构：

[1] ASTAR, IMRE, Singapore 117602, Singapore

[2] Univ New S Wales, CAMD, Sch Chem Sci & Engn, Sydney, NSW 2052, Australia

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2009年 / 30卷 / 12期

基金：

澳大利亚研究理事会;

关键词：

amphiphilic block copolymers; cyanopropyl dithiobenzoate; dimethylaminoethyl methacrylate; micelles; pH-responsive polymers; pentafluorostyrene; RAFT; self-assembly; LIVING RADICAL POLYMERIZATION; CROSS-LINKED MICELLES; RAFT POLYMERIZATION; STAR POLYMERS; STYRENE; METHACRYLATE; TRIBLOCK; BEHAVIOR; DIBLOCK; ACID;

D O I：

10.1002/marc.200800799

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We report the synthesis of a novel pH-responsive amphiphilic block copolymer poly(dimethylaminoethyl methacrylate)-block-poly(pentafluoro styrene) (PDMAEMA-b-PPFS) using RAFT-mediated living radical polymerization. Copolymer micelle formation, in aqueous solution, was investigated using fluorescence spectroscopy, static and dynamic light scattering (SLS and DLS), and transmission electron microscopy (TEM). DLS and SLS measurements revealed that the diblock copolymers form spherical micelles with large aggregation numbers, N-agg approximate to 30 where the dense PPFS core is surrounded by dangling PDMAEMA chains as the micelle Corona. The hydrodynamic radii, R-h of these micelles is large, at pH 2-5 as the protonated PDMAEMA segments swell the micelle Corona. Above pH 5, the PDMAEMA segments are gradually deprotonated, resulting in a lower osmotic pressure and enhanced hydrophobicity within the micelle, thus decreasing the R-h. However, the radius of gyration, R-g remains independent of pH as the dense PPFS cores predominate.

引用

页码：1002 / 1008

页数：7

共 52 条

[11] RAFT-based synthesis and characterization of ABC versus ACB triblock copolymers containing tert-butyl acrylate, isoprene, and styrene blocksa [J].