Activation of autophagic pathways is related to growth inhibition and senescence in cutaneous squamous cell carcinoma

被引：10

作者：

Choi, So Ra ^{[1
]}

Chung, Bo Young ^{[1
]}

Kim, Seong Who ^{[2
]}

Kim, Chang Deok ^{[3
,4
]}

Yun, Woo Jin ^{[1
]}

Lee, Mi Woo ^{[1
]}

Choi, Jee Ho ^{[1
]}

Chang, Sung Eun ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Dermatol, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Biochem & Mol Biol, Seoul 138736, South Korea

[3] Chungnam Natl Univ, Sch Med, Dept Dermatol, Taejon, South Korea

[4] Chungnam Natl Univ, Sch Med, Res Inst Med Sci, Taejon, South Korea

来源：

EXPERIMENTAL DERMATOLOGY | 2014年 / 23卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

activating transcription factor 3; autophagy; cutaneous squamous cell carcinoma; growth inhibition; senescence; SKIN-CANCER; TRANSCRIPTION FACTOR-3; RESPONSE GENE; P53; ATF3; DEGRADATION; EXPRESSION; BECLIN-1; SURVIVAL; TUMORIGENESIS;

D O I：

10.1111/exd.12515

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cutaneous squamous cell carcinoma (SCC) is a very common resectable cancer; however, cutaneous SCC is highly resistant to chemotherapy if metastasis develops. Activating transcription factor 3 (ATF3) has been suggested as a marker of advanced or metastatic cutaneous SCC. Autophagy is one of the most important mechanisms in cancer biology and commonly induced by in vitro serum starvation. To investigate the role of autophagy activation in cutaneous SCC, we activated autophagic pathways by serum starvation in SCC13 and ATF3-overexpressing SCC13 (ATF3-SCC13) cell lines. ATF3-SCC13 cells demonstrated high proliferative capacity and low p53 and autophagy levels in comparison with control SCC13 cells under basal conditions. Intriguingly, autophagic stimulation via serum starvation resulted in growth inhibition and senescence in both cells, while ATF3-SCC13 cells further demonstrated growth inhibition and senescence. Apoptosis was not significantly induced by autophagy activation. Taken together, autophagy activation may be a promising antitumor approach for advanced cutaneous SCC.

引用

页码：718 / 724

页数：7

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