Intercellular adhesion molecule 1/2 and E-selectin in plasma cell mastitis: immunohistochemical study of 35 cases

被引：15

作者：

Dong, Yu ^{[1
,2
,3
]}

Yu, Jian-Jun ^{[2
,3
]}

Shibahara, Yukiko ^{[1
]}

Lu, Huai-Sheng ^{[4
]}

He, Hai-Yan ^{[4
]}

Liu, Jian-Dong ^{[4
]}

Chen, Shi-Fan ^{[1
,5
]}

Wang, Lin ^{[1
,6
]}

Zhang, Ye ^{[7
]}

Felizola, Saulo J. A. ^{[1
]}

Chan, Monica S. M. ^{[1
]}

Ono, Katsuhiko ^{[1
]}

Ishida, Takanori ^{[8
]}

Ohuchi, Noriaki ^{[8
]}

Sasano, Hironobu ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Pathol, Sendai, Miyagi 9808575, Japan

[2] Ningxia Med Univ, Dept Surg Oncol, Ningxia 750021, Peoples R China

[3] Ningxia Peoples Hosp, Dept Breast Surg, Ningxia 750021, Peoples R China

[4] Ningxia Peoples Hosp, Dept Pathol, Ningxia 750021, Peoples R China

[5] Jilin Univ, Hosp 2, Dept Pathol, Changchun 130041, Peoples R China

[6] Harbin Med Univ, Daqing Branch, Dept Physiol, Harbin, Peoples R China

[7] Tohoku Univ, Grad Sch Dent, Div Oral Physiol, Sendai, Miyagi 9808575, Japan

[8] Tohoku Univ, Grad Sch Med, Dept Surg, Sendai, Miyagi 9808575, Japan

来源：

HUMAN PATHOLOGY | 2014年 / 45卷 / 03期

关键词：

Breast; Cell adhesion; Inflammation; Plasma cell mastitis; VASCULAR ENDOTHELIAL-CELLS; PERIDUCTAL MASTITIS; ANTIGENS; INVITRO; ICAM-1;

D O I：

10.1016/j.humpath.2013.06.025

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Plasma cell mastitis (PCM) is one of the most frequently encountered inflammatory diseases of the nonlactating breast. Histologically, PCM is characterized by infiltration of relatively abundant plasma cells into the mammary ducts Its pathogenesis has remained unknown. In this study, we immunolocalized intercellular adhesion molecule (ICAM) 1 and 2 and E-selectin, all of which play pivotal roles in the inflammatory process, in 35 cases of PCM. We then compared the results with those of non-PCM and nonpathologic breast tissue. In the ductal epithelium, ICAM-1 immunoreactivity was significantly more pronounced in PCM than in non-PCM (P = .045). Both ICAM-1 (P < .001) and ICAM-2 (P = .001) were significantly more pronounced in PCM than in nonpathologic breast tissue. However, no significant differences in ICAM-2 and E-selectin immunoreactivity were detected between ductal epithelium of PCM and non-PCM. ICAM-1, but not ICAM-2 or E-selectin, demonstrated significantly higher immunoreactivity in endothelial cells of PCM than in nonpathologic breast (P < .001). These results all suggest that ICAM-1 in both ductal epithelium and endothelium plays important roles in the inflammatory process of PCM, possibly through margination, extravasation, and attachment of plasma cells and lymphocytes, which may result in continuous inflammatory cell homing to ductal epithelial cells. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：606 / 610

页数：5

共 14 条

[11]

NAGARATNAM N, 1958, Postgrad Med J, V34, P654

[12]

Su L, 2009, NING XIA YI KE DA XU, V31, P356

[13]

Sun RW, 2001, CLIN LAB DIAGNOSIS, P318

[14] EXPRESSION OF THE ADHESION MOLECULE ICAM-1 AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ANTIGENS ON HUMAN TUMOR-CELLS IS REQUIRED FOR THEIR INTERACTION WITH AUTOLOGOUS LYMPHOCYTES INVITRO [J].

VANKY, F ;

WANG, P ;

PATARROYO, M ;

KLEIN, E .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 1990, 31 (01) :19-27

← 1 2 →