Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

被引：30

作者：

Hu, Weigao ^{[1
]}

Zheng, Jia ^{[1
]}

Li, Jianxiao ^{[1
]}

Liu, Bifu ^{[1
]}

Wu, Wanqing ^{[1
]}

Liu, Haiyang ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 24期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; PHENANTHRIDINE DERIVATIVES; EFFICIENT SYNTHESIS; O-AMINOPHENOLS; GAMMA-LACTONES; IONIC LIQUIDS; ARYL HALIDES; INSERTION;

D O I：

10.1021/acs.joc.6b02227

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C-C, C=O, and C-N bonds were constructed in this transformation with isocyanide serving as both C and N sources.

引用

页码：12451 / 12458

页数：8

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