Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

被引：30
|
作者：
Hu, Weigao [1 ]
Zheng, Jia [1 ]
Li, Jianxiao [1 ]
Liu, Bifu [1 ]
Wu, Wanqing [1 ]
Liu, Haiyang [1 ]
Jiang, Huanfeng [1 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 24期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; PHENANTHRIDINE DERIVATIVES; EFFICIENT SYNTHESIS; O-AMINOPHENOLS; GAMMA-LACTONES; IONIC LIQUIDS; ARYL HALIDES; INSERTION;
D O I：
10.1021/acs.joc.6b02227
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C-C, C=O, and C-N bonds were constructed in this transformation with isocyanide serving as both C and N sources.
引用
收藏
页码：12451 / 12458
页数：8
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