Mechanisms of epitranscriptomic gene regulation

被引：14

作者：

Seo, Kyung W. ^{[1
]}

Kleiner, Ralph E. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

BIOPOLYMERS | 2021年 / 112卷 / 01期

关键词：

MESSENGER-RNA METHYLATION; NUCLEAR-RNA; M(6)A RNA; SEX DETERMINATION; CRYSTAL-STRUCTURE; YTH DOMAIN; N-6-METHYLADENOSINE; REVEALS; PROTEIN; 5-METHYLCYTOSINE;

D O I：

10.1002/bip.23403

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical modifications on RNA can regulate fundamental biological processes. Recent efforts have illuminated the chemical diversity of posttranscriptional ("epitranscriptomic") modifications on eukaryotic messenger RNA and have begun to elucidate their biological roles. In this review, we discuss our current molecular understanding of epitranscriptomic RNA modifications and their effects on gene expression. In particular, we highlight the role of modifications in mediating RNA-protein interactions, RNA structure, and RNA-RNA base pairing, and how these macromolecular interactions control biological processes in the cell.

引用

页数：12

共 126 条

[1] HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events [J].

Alarcon, Claudio R. ;

Goodarzi, Hani ;

Lee, Hyeseung ;

Liu, Xuhang ;

Tavazoie, Saeed ;

Tavazoie, Sohail F. .

CELL, 2015, 162 (06) :1299-1308

[2] N6-methyladenosine marks primary microRNAs for processing [J].

Alarcon, Claudio R. ;

Lee, Hyeseung ;

Goodarzi, Hani ;

Halberg, Nils ;

Tavazoie, Sohail F. .

NATURE, 2015, 519 (7544) :482-+

[3] Long non-coding RNAs as targets for cytosine methylation [J].

Amort, Thomas ;

Souliere, Marie F. ;

Wille, Alexandra ;

Jia, Xi-Yu ;

Fiegl, Heidi ;

Woerle, Hildegard ;

Micura, Ronald ;

Lusser, Alexandra .

RNA BIOLOGY, 2013, 10 (06) :1003-1009

[4] Acetylation of Cytidine in mRNA Promotes Translation Efficiency [J].

Arango, Daniel ;

Sturgill, David ;

Alhusaini, Najwa ;

Dillman, Allissa A. ;

Sweet, Thomas J. ;

Hanson, Gavin ;

Hosogane, Masaki ;

Sinclair, Wilson R. ;

Nanan, Kyster K. ;

Mandler, Mariana D. ;

Fox, Stephen D. ;

Zengeya, Thomas T. ;

Andresson, Thorkell ;

Meier, Jordan L. ;

Coller, Jeffery ;

Oberdoerffer, Shalini .

CELL, 2018, 175 (07) :1872-+

[5] In Vitro Selection with a Site-Specifically Modified RNA Library Reveals the Binding Preferences of N6-Methyladenosine Reader Proteins [J].

Arguello, A. Emilia ;

Leach, Robert W. ;

Kleiner, Ralph E. .

BIOCHEMISTRY, 2019, 58 (31) :3386-3395

[6] RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome [J].

Arguello, A. Emilia ;

DeLiberto, Amanda N. ;

Kleiner, Ralph E. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (48) :17249-17252

[7] Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders [J].

Blanco, Sandra ;

Dietmann, Sabine ;

Flores, Joana V. ;

Hussain, Shobbir ;

Kutter, Claudia ;

Humphreys, Peter ;

Lukk, Margus ;

Lombard, Patrick ;

Treps, Lucas ;

Popis, Martyna ;

Kellner, Stefanie ;

Hoelter, Sabine M. ;

Garrett, Lillian ;

Wurst, Wolfgang ;

Becker, Lore ;

Klopstock, Thomas ;

Fuchs, Helmut ;

Gailus-Durner, Valerie ;

de Angelis, Martin Hrabe ;

Karadottir, Ragnhildur T. ;

Helm, Mark ;

Ule, Jernej ;

Gleeson, Joseph G. ;

Odom, Duncan T. ;

Frye, Michaela .

EMBO JOURNAL, 2014, 33 (18) :2020-2039

[8] MODOMICS: a database of RNA modification pathways. 2017 update [J].

Boccaletto, Pietro ;

Machnicka, Magdalena A. ;

Purta, Elzbieta ;

Piatkowski, Pawe ;

Baginski, Blazej ;

Wirecki, Tomasz K. ;

de Crecy-Lagard, Valerie ;

Ross, Robert ;

Limbach, Patrick A. ;

Kotter, Annika ;

Helm, Mark ;

Bujnicki, Janusz M. .

NUCLEIC ACIDS RESEARCH, 2018, 46 (D1) :D303-D307

[9]

BOKAR JA, 1994, J BIOL CHEM, V269, P17697

[10] mRNA structure determines modification by pseudouridine synthase 1 [J].

Carlile, Thomas M. ;

Martinez, Nicole M. ;

Schaening, Cassandra ;

Su, Amanda ;

Bell, Tristan A. ;

Zinshteyn, Boris ;

Gilbert, Wendy, V .

NATURE CHEMICAL BIOLOGY, 2019, 15 (10) :966-+

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