Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood

被引：128
作者：
Mose, Tina
Mortensen, Gerda K.
Hedegaard, Morten
Knudsen, Lisbeth E.
机构：
[1] Univ Copenhagen, Dept Environm & Occupat Hlth, Inst Publ Hlth, Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Dept Growth & Reprod, Copenhagen, Denmark
[3] Copenhagen Univ Hosp, Clin Obstet, Copenhagen, Denmark
来源：
REPRODUCTIVE TOXICOLOGY | 2007年 / 23卷 / 01期
关键词：
placenta perfusion; phthalate monoesters; plasticizers; pregnancy; fetal exposure;
D O I：
10.1016/j.reprotox.2006.08.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Fetal exposure to phthalates may be associated with adverse reproductive effects, including cryptorchidism and decreased semen quality. Information about human placental transfer is needed to qualify the hypotheses. A dual recirculating placenta perfusion system to monitor concentrations of eight phthalate monoesters in fetal and maternal perfusates was established. In addition to perfusate background measures of phthalate monoesters, the concentrations in umbilical cord plasma and placenta tissue were measured. Monomethyl phthalate (mMP), monoethyl phthalate (mEP), monobutyl phthalate (mBP), and mono (2-ethyl-hexyl) phthalate (mEHP) were detected in both maternal and fetal perfusate, demonstrating a release of compounds from tissue or blood to perfusates. The distribution of compounds between perfusate, umbilical cord plasma, and tissue was in accordance with the physical-chemical properties of the compounds. Results from the present study of compounds residing in the tissue are essential before studying human transplacental transfer, storage, and metabolism of selected phthalate monoesters. (c) 2006 Elsevier Inc. All rights reserved.
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收藏
页码：83 / 91
页数：9
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