Determinants of Ethnic Differences in Cytomegalovirus, Epstein-Barr Virus, and Herpes Simplex Virus Type 1 Seroprevalence in Childhood

被引:37
作者
Jansen, Michelle A. E. [1 ,2 ,3 ]
van den Heuvel, Diana [3 ]
Bouthoorn, Selma H. [1 ,4 ]
Jaddoe, Vincent W. V. [1 ,2 ,5 ]
Hooijkaas, Herbert
Raat, Hein [4 ]
Fraaij, Pieter L. A. [2 ,6 ]
van Zelm, Menno C. [3 ,7 ]
Moll, Henriette A. [2 ]
机构
[1] Univ Med Ctr, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands
[2] Sophia Childrens Univ Hosp, Dept Pediat, Rotterdam, Netherlands
[3] Univ Med Ctr, Erasmus MC, Dept Immunol, Rotterdam, Netherlands
[4] Univ Med Ctr, Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands
[5] Univ Med Ctr, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
[6] Univ Med Ctr, Erasmus MC, Dept Virosci, Rotterdam, Netherlands
[7] Monash Univ, Cent Clin Sch, Dept Pathol & Immunol, Melbourne, Vic 3004, Australia
关键词
AGE-SPECIFIC PREVALENCE; BURKITT-LYMPHOMA; DAY-CARE; INFECTION; CHILDREN; HERPESVIRUSES; ANTIBODIES; EPIDEMIOLOGY; PATHOGENESIS; DISEASES;
D O I
10.1016/j.jpeds.2015.11.014
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To identify whether there are ethnic differences in cytomegalovirus (CMV), Epstein-Barr virus (EBV), and herpes simplex virus type 1 (HSV-1) seroprevalence rates in children at 6 years of age, and when present, to evaluate how these differences can be explained by sociodemographic and environmental factors. Study design This study was embedded within a multi-ethnic population-based prospective cohort study. Serum IgG levels against CMV, EBV, and HSV-1 were measured by enzyme-linked immunosorbent assay in 4464 children (median age 6.0 years). Information on demographics and characteristics were assessed by questionnaires. Herpesvirus seroprevalences between Surinamese-Creole, Surinamese-Hindustani, Turkish, Moroccan, Cape Verdean Antillean, and Native Dutch children were compared. Results Non-Western ethnicity was an independent risk factor for CMV (aOR, 2.16; 95% CI 1.81-2.57), EBV (1.76; 1.48-2.09), and HSV-1 seropositivity (1.52; 1.39-1.66). Among the ethnic groups, CMV seroprevalences ranged between 29% and 65%, EBV between 43% and 69%, and HSV-1 between 13% and 39%. Low family net household income, low maternal educational level, crowding, and lifestyle factors explained up to 48% of the ethnic differences in HSV-1 seroprevalences, and up to 39% of the ethnic differences in EBV seroprevalences. These factors did not explain ethnic differences in CMV seroprevalences. Conclusions Socioeconomic position and factors related to lifestyle explain only a part of the large ethnic differences in EBV and HSV-1 seroprevalences, whereas they do not explain ethnic differences in CMV seroprevalences in childhood.
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页码:126 / +
页数:15
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