Inhibition of matrix metalloproteinases: An examination of the S1' pocket

被引:28
作者
Miller, A
Askew, M
Beckett, RP
Bellamy, CL
Bone, EA
Coates, RE
Davidson, AH
Drummond, AH
Huxley, P
Martin, FM
Saroglou, L
Thompson, AJ
vanDijk, SE
Whittaker, M
机构
[1] British Biotech Pharmaceuticals Ltd., Oxford OX4 5LY, Watlington Rd.
关键词
D O I
10.1016/S0960-894X(96)00602-6
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Peptidomimetic carboxylate- and hydroxamate-based inhibitors of matrix metalloproteinases containing extended P1' groups have been prepared. Potent inhibition and good selectivity for MMP-2 has been observed for the compounds produced. (C) 1997, Elsevier Science Ltd.
引用
收藏
页码:193 / 198
页数:6
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