The ER-mitochondria couple: In life and death from steroidogenesis to tumorigenesis

被引：19

作者：

Doghman-Bouguerra, Mabrouka ^{[1
,2
,3
]}

Lalli, Enzo ^{[1
,2
,3
,4
]}

机构：

[1] Univ Cote Azur, Sophia Antipolis, France

[2] CNRS, UMR 7275, Paris, France

[3] CNRS, Int Associated Lab, NEOGENEX, Paris, France

[4] INSERM, Paris, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 441卷 / 0C期

关键词：

Adrenal cancer; Steroidogenesis; Mitochondria associated membrane MAM; Apoptosis; ENDOPLASMIC-RETICULUM; CHOLESTEROL TRANSPORT; REGULATES APOPTOSIS; MEMBRANE-FRACTION; CELL LIFE; RAT-LIVER; CALCIUM; PROTEIN; IDENTIFICATION; FISSION;

D O I：

10.1016/j.mce.2016.08.050

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Steroidogenesis is a multistep process where interorganelle communications between the endoplasmic reticulum and mitochondria are critical. These intimate interactions physically occur through the Mitochondria-Associated ER membranes called MAMs. MAMs play important roles in mitochondrial morphology and in many cellular functions ranging from lipid metabolism, to calcium signaling and apoptosis together with a critical effect on steroidogenesis. Moreover, our recent characterization of new MAM resident proteins in adrenocortical cells extends the function of MAM in the mechanism of resistance of cancer cells to apoptotic stimuli and offers new perspectives in targeted therapeutic approaches for adrenocortical tumorigenesis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：176 / 184

页数：9

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