Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition

被引：176

作者：

Doyon, Nicolas ^{[1
,2
]}

Vinay, Laurent ^{[3
,4
]}

Prescott, Steven A. ^{[5
,6
]}

De Koninck, Yves ^{[1
,7
]}

机构：

[1] Inst Univ Sante Mentale Quebec, Quebec City, PQ G1J 2G3, Canada

[2] Univ Laval, Dept Math & Stat, Quebec City, PQ G1V 0A6, Canada

[3] CNRS, Inst Neurosci Timone, Team P3M, UMR 7289, F-13385 Marseille, France

[4] Aix Marseille Univ, F-13385 Marseille, France

[5] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada

[6] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

[7] Univ Laval, Dept Psychiat & Neurosci, Quebec City, PQ G1V 0A6, Canada

来源：

NEURON | 2016年 / 89卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

VENTRAL TEGMENTAL AREA; K-CL COTRANSPORTER; LAMINA-I NEURONS; IMPERMEANT ANIONS ESTABLISH; HIGH-CONDUCTANCE STATE; INTRACELLULAR CHLORIDE; PYRAMIDAL NEURONS; TRANSPORTER KCC2; DOWN-REGULATION; PATHOLOGICAL PAIN;

D O I：

10.1016/j.neuron.2016.02.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fast synaptic inhibition relies on tight regulation of intracellular Cl-. Chloride dysregulation is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, the consequences of Cl- dysregulation are multifaceted and best understood in terms of a dynamical system involving complex interactions between multiple processes operating on many spatiotemporal scales. This dynamical perspective helps explain many unintuitive manifestations of Cl- dysregulation. Here we discuss how taking into account dynamical regulation of intracellular Cl- is important for understanding how synaptic inhibition fails, how to best detect that failure, why Cl- regulation is energetically so expensive, and the overall consequences for therapeutics.

引用

页码：1157 / 1172

页数：16

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