Novel Synthesis and Characterization of Thiosemicarbazone Compounds Containing 4-Acyl-2-pyrazolin-5-ones

被引：9
|
作者：
Rana, Arjun K. [1 ]
Parekh, Nayan R. [1 ,2 ]
Dabhi, Harish R. [1 ]
Nadkarni, Sunil S. [2 ]
机构：
[1] Gujarat Univ, Navajivan Sci Coll, Ahmadabad, Gujarat, India
[2] Torrent Res Ctr Village Bhat, Ahmadabad, Gujarat, India
来源：
E-JOURNAL OF CHEMISTRY | 2009年 / 6卷 / 03期
关键词：
4-Acyl-3-methyl-1-(4 '-methylphenyl)-2-pyrazolin-5-one; Thiosemicarbazone and Amine substitution; Biological activity; BIOLOGICAL-ACTIVITY; PYRAZOLONE-RING; COMPLEXES; DERIVATIVES; COPPER(II); CU(II);
D O I：
10.1155/2009/472530
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel synthesis of 4-acylthiosemicarbazone-3-methyl-1-(4'-methylphenyl)-2-pyrazolin-5-one by condensation of 4-acyl-3-methyl-1-(4'-methylphenyl)-2- pyrazolin-5-one with thiosemicarbazide is carried out. The compounds were characterized on the basis of elemental analysis, IR, H-1 NMR, Mass, DSC and C-13 NMR spectral data. The structures were investigated for their antibacterial and antifungal activity. They are very essential to study on cerebral infarction (Free radical scavenger). A single crystal X-ray study of this thiosemicarbazones and their metal complexes is in progress.
引用
收藏
页码：747 / 752
页数：6
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