Novel Synthesis and Characterization of Thiosemicarbazone Compounds Containing 4-Acyl-2-pyrazolin-5-ones

被引：9
|
作者：
Rana, Arjun K. [1 ]
Parekh, Nayan R. [1 ,2 ]
Dabhi, Harish R. [1 ]
Nadkarni, Sunil S. [2 ]
机构：
[1] Gujarat Univ, Navajivan Sci Coll, Ahmadabad, Gujarat, India
[2] Torrent Res Ctr Village Bhat, Ahmadabad, Gujarat, India
来源：
E-JOURNAL OF CHEMISTRY | 2009年 / 6卷 / 03期
关键词：
4-Acyl-3-methyl-1-(4 '-methylphenyl)-2-pyrazolin-5-one; Thiosemicarbazone and Amine substitution; Biological activity; BIOLOGICAL-ACTIVITY; PYRAZOLONE-RING; COMPLEXES; DERIVATIVES; COPPER(II); CU(II);
D O I：
10.1155/2009/472530
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel synthesis of 4-acylthiosemicarbazone-3-methyl-1-(4'-methylphenyl)-2-pyrazolin-5-one by condensation of 4-acyl-3-methyl-1-(4'-methylphenyl)-2- pyrazolin-5-one with thiosemicarbazide is carried out. The compounds were characterized on the basis of elemental analysis, IR, H-1 NMR, Mass, DSC and C-13 NMR spectral data. The structures were investigated for their antibacterial and antifungal activity. They are very essential to study on cerebral infarction (Free radical scavenger). A single crystal X-ray study of this thiosemicarbazones and their metal complexes is in progress.
引用
收藏
页码：747 / 752
页数：6
相关论文
共 50 条
  • [1] Synthesis and physico-chemical studies on nickel(II) chelates of some tetradentate bisketimino derivatives of 4-acyl-2-pyrazolin-5-ones
    Raj, DS
    Parmar, NJ
    Shah, JR
    SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 2004, 34 (04): : 697 - 711
  • [2] SYNTHESIS AND CHARACTERIZATION OF 4-ACYL-3-METHYL-2-PYRAZOLIN-5-ONE COMPLEXES OF ALUMINUM
    SINGH, YP
    RAI, AK
    SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 1982, 12 (01): : 85 - 102
  • [3] Synthesis, characterization and analgesic activity of new 4-arylhydrazono-3-methoxymethyl-2-pyrazolin-5-ones
    Ergenç, N
    Çapan, G
    Demirdamar, R
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2001, 51 (02): : 118 - 124
  • [4] 1-PHENYL-2-ACYL-3-AMINO-2-PYRAZOLIN-5-ONES FROM 1-PHENYL-3-AZIDOCARBONYL-2-PYRAZOLIN-5-ONES
    HENDESS, RW
    JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (15): : 2400 - &
  • [5] SYNTHESIS OF 3-ARYL-4-(2-HYDROXYETHYL)-2-PYRAZOLIN-5-ONES AS POSSIBLE ANTICONVULSANT COMPOUNDS
    BALANI, RA
    KULKARNI, KD
    INDIAN JOURNAL OF CHEMISTRY, 1963, 1 (09): : 407 - &
  • [6] 4-(5-HYDROXY-4-PYRAZOLYLIMINO)-2-PYRAZOLIN-5-ONES AND THEIR METAL-CHELATES .2. 4-(5-HYDROXY-4-PYRAZOLYLMETHYLENE)-2-PYRAZOLIN-5-ONES AND RELATED COMPOUNDS
    HANSEL, W
    JUSTUS LIEBIGS ANNALEN DER CHEMIE, 1976, (09): : 1680 - 1688
  • [7] SYNTHESIS OF 3-UREIDO-2-PYRAZOLIN-5-ONES
    NAKATANI, M
    YAMASHITA, K
    TOSA, S
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1981, 101 (04): : 323 - 328
  • [8] SYNTHESIS OF 2-PYRAZOLIN-5-ONES AND THEIR MEDICINAL PROPERTIES
    OJHA, AC
    JAIN, RK
    AGRAWAL, M
    NATIONAL ACADEMY SCIENCE LETTERS-INDIA, 1983, 6 (05): : 157 - 158
  • [9] Synthesis and structure of fluorine-containing 3-pyrazolin-5-ones
    T. I. Gorbunova
    D. N. Bazhin
    M. I. Kodess
    E. G. Matochkina
    P. A. Slepukhin
    A. Ya. Zapevalov
    V. I. Saloutin
    Russian Journal of Organic Chemistry, 2009, 45 : 1670 - 1674
  • [10] Synthesis and Structure of Fluorine-Containing 3-Pyrazolin-5-ones
    Gorbunova, T. I.
    Bazhin, D. N.
    Kodess, M. I.
    Matochkina, E. G.
    Slepukhin, P. A.
    Zapevalov, A. Ya.
    Saloutin, V. I.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 45 (11) : 1670 - 1674
12345