DMSO as a Switchable Alkylating Agent in Heteroarene C-H Functionalization

被引：55

作者：

Garza-Sanchez, R. Aleyda ^{[1
]}

Patra, Tuhin ^{[1
]}

Tlahuext-Aca, Adrian ^{[1
]}

Strieth-Kalthoff, Felix ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 40期

关键词：

C-H functionalization; heteroarenes; methylation; methylthiomethylation; photoredox catalysis; NUCLEOPHILIC CHARACTER; COMBINING PHOTOREDOX; DIMETHYL-SULFOXIDE; METHYLATION; OXIDATION; RADICALS; ALCOHOLS; ACIDS; GENERATION; CATALYSIS;

D O I：

10.1002/chem.201802352

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report a novel strategy for the activation of DMSO to act as a versatile alkylating agent in heteroarene C-H functionalization. This direct, simple, and mild switch between methylation/trideuteromethylation and methylthiomethylation of heteroarenes was achieved under reagent-controlled photoredox catalysis conditions. The proposed mechanism is supported by both experimental and computational studies.

引用

页码：10064 / 10068

页数：5

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