Crystal structures of cocrystals of 2,7-dihydroxy-naphthalene with isoniazid and piracetam

被引：0

作者：

Saulo Gonzalez-Gonzalez, Juan ^{[1
]}

Valiente Flores, Miguel Eulalio ^{[1
]}

Flores-Alamo, Marcos ^{[2
]}

Macias-Lopez, Elizabeth ^{[3
]}

Javier Martinez-Martinez, Francisco ^{[3
]}

Garcia-Ortega, Hector ^{[2
]}

机构：

[1] Univ Canada, Inst Farmacobiol, Carretera Teotitlan, Teotitlan De Flores Mago 68540, Oaxaca, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Quim, Ciudad De Mexico 04510, Mexico

[3] Univ Colima, Fac Ciencias Quim, Km 9 Carretera Colima Coquimatlan, Colima 28400, Mexico

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 2022年 / 78卷

关键词：

cocrystal; piracetam; isoniazid; 2,7-dihydroxynaphthalene; crystal structure; IR spectroscopy; API; active pharmaceutical ingredient; solvent-assisted grinding; GRAPH-SET ANALYSIS; PHARMACEUTICAL COCRYSTALS; HYDROGEN-BOND; POLYMORPHS; PATTERNS;

D O I：

10.1107/S2053229622003734

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cocrystals of 2,7-dihydroxynaphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN-INH [C10H8O2 center dot-C6H7N3O, (I)], and piracetam [2-(2-oxopyrrolidin-1-yl)acetamide] (PIR), denoted DHN-PIR [C10H8O2 center dot C6H10N2O2, (II)], were obtained by the solvent-assisted grinding method and characterized by IR spectroscopy, powder X-ray diffraction and single-crystal X-ray diffraction. Cocrystal (I) crystallized in the triclinic space group P (1) over bar and showed a 2:2 stoichiometry. DHN and INH molecules are connected by O-H center dot center dot center dot N(pyridine) and O-H center dot center dot center dot N(hydrazide) hydrogen bonds. Cocrystal (II) crystallized in the space group Pca2(1) with a 1:1 stoichiometry. DHN and PIR molecules are connected by O-H center dot center dot center dot O=C hydrogen bonds. The supramolecular architecture of cocrystal (I) showed interlinked supramolecular tapes; meanwhile, in cocrystal (II), interlinked supramolecular sheets were observed.

引用

页码：280 / +

页数：19

共 24 条

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