The cytogenetic effects of food sweetener maltitol in human peripheral lymphocytes

被引：7
作者：
Canimoglu, Semir
Rencuzogullari, Eyyup [1 ]
机构：
[1] Cukurova Univ, Fac Sci & Letters, Dept Biol, TR-01330 Adanna, Turkey
[2] Cukurova Univ, Nat & Appl Sci Inst, Dept Biol, TR-01330 Adanna, Turkey
来源：
DRUG AND CHEMICAL TOXICOLOGY | 2006年 / 29卷 / 03期
关键词：
chromosome aberrations; human peripheral lymphocytes; maltitol; micronucleus; sister chromatid exchange;
D O I：
10.1080/01480540600651600
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effects of the low-calorie artifical sweetener maltitol (E965), a sugar alcohol (Polyol), on sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus formation (MN) were investigated in human peripheral lymphocytes. Maltitol did not induce SCE at all concentrations (1.25, 2.5, and 5 mg/mL) and treatment periods (24 and 48 h). Maltitol induced CA, although not statistically significantly. Maltitol induced the frequency of MN at 24 and 48 h in a non-dose-dependent manner. In addition, maltitol did not decrease the replication index (RI) and the mitotic index (MI) at all concentrations and treatment periods. Maltitol did not alter the pH and osmolality of the medium. In conclusion, it can be concluded that maltitol has a weak genotoxic potential and it appears non-cytotoxic to human peripheral lymphocytes in vitro .
引用
收藏
页码：269 / 278
页数：10
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