Extreme sensitive metasensor for targeted biomarkers identification using colloidal nanoparticles-integrated plasmonic unit cells

被引:127
作者
Ahmadivand, Arash [1 ]
Gerislioglu, Burak [1 ]
Tomitaka, Asahi [2 ]
Manickam, Pandiaraj [3 ,4 ]
Kaushik, Ajeet [2 ]
Bhansali, Shekhar [3 ]
Nair, Madhavan [2 ]
Pala, Nezih [1 ]
机构
[1] Florida Int Univ, Dept Elect & Comp Engn, 10555 W Flagler St, Miami, FL 33174 USA
[2] Florida Int Univ, Herbert Wertheim Coll Med, Ctr Personalized NanoMed, Inst Neurolmmune Pharmacol,Dept Immunol, Miami, FL 33199 USA
[3] Florida Int Univ, Dept Elect & Comp Engn, Bio MEMS & Microsyst Lab, 10555 W Flagler St, Miami, FL 33174 USA
[4] Cent Elect Res Inst, CSJR, Electrod & Electrocatal Div, Karaikkudi 630006, Tamil Nadu, India
基金
美国国家卫生研究院;
关键词
TERAHERTZ METAMATERIAL; INDUCED TRANSPARENCY; CHARGE-TRANSFER; SLOW LIGHT; TECHNOLOGY; PLATFORM; OPTICS; DARK;
D O I
10.1364/BOE.9.000373
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Engineered terahertz (THz) plasmonic metamaterials have emerged as promising platforms for quick infection diagnosis, cost-effective and real-time pharmacology applications owing to their non-destructive and harmless interaction with biological tissues in both in vivo and in vitro assays. As a recent member of THz metamaterials family, toroidal metamaterials have been demonstrated to be supporting high-quality sharp resonance modes. Here we introduce a THz metasensor based on a plasmonic surface consisting of metamolecules that support ultra-narrow toroidal resonances excited by the incident radiation and demonstrate detection of an ultralow concertation targeted biomarker. The toroidal plasmonic metasurface was designed and optimized through extensive numerical studies and fabricated by standard microfabrication techniques. The surface then functionalized by immobilizing the antibody for virus-envelope proteins (ZIKV-EPs) for selective sensing. We sensed and quantified the ZIKV-EP in the assays by measuring the spectral shifts of the toroidal resonances while varying the concentration. In an improved protocol, we introduced gold nanoparticles (GNPs) decorated with the same antibodies onto the metamolecules and monitored the resonance shifts for the same concentrations. Our studies verified that the presence of GNPs enhances capturing of biomarker molecules in the surrounding medium of the metamaterial. By measuring the shift of the toroidal dipolar momentum (up to Delta omega similar to 0.35 cm(-1)) for different concentrations of the biomarker proteins, we analyzed the sensitivity, repeatability, and limit of detection (LoD) of the proposed toroidal THz metasensor. The results show that up to 100-fold sensitivity enhancement can be obtained by utilizing plasmonic nanoparticles-integrated toroidal metamolecules in comparison to analogous devices. This approach allows for detection of low molecular-weight biomolecules (approximate to 13 kDa) in diluted solutions using toroidal THz plasmonic unit cells. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码:373 / 386
页数:14
相关论文
共 75 条
[1]   Large-Modulation-Depth Polarization-Sensitive Plasmonic Toroidal Terahertz Metamaterial [J].
Ahmadivand, Arash ;
Gerislioglu, Burak ;
Pala, Nezih .
IEEE PHOTONICS TECHNOLOGY LETTERS, 2017, 29 (21) :1860-1863
[2]   Active Control over the Interplay between the Dark and Hidden Sides of Plasmonics Using Metallodielectric Au-Ge2Sb2Te5 Unit Cells [J].
Ahmadivand, Arash ;
Gerislioglu, Burak ;
Pala, Nezih .
JOURNAL OF PHYSICAL CHEMISTRY C, 2017, 121 (36) :19966-19974
[3]   Rapid Detection of Infectious Envelope Proteins by Magnetoplasmonic Toroidal Metasensors [J].
Ahmadivand, Arash ;
Gerislioglu, Burak ;
Manickam, Pandiaraj ;
Kaushik, Ajeet ;
Bhansali, Shekhar ;
Nair, Madhavan ;
Pala, Nezih .
ACS SENSORS, 2017, 2 (09) :1359-1368
[4]   Excitation of Terahertz Charge Transfer Plasmons in Metallic Fractal Structures [J].
Ahmadivand, Arash ;
Gerislioglu, Burak ;
Sinha, Raju ;
Vabbina, Phani Kiran ;
Karabiyik, Mustafa ;
Pala, Nezih .
JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES, 2017, 38 (08) :992-1003
[5]   Tunable THz wave absorption by graphene-assisted plasmonic metasurfaces based on metallic split ring resonators [J].
Ahmadivand, Arash ;
Sinha, Raju ;
Karabiyik, Mustafa ;
Vabbina, Phani Kiran ;
Gerislioglu, Burak ;
Kaya, Serkan ;
Pala, Nezih .
JOURNAL OF NANOPARTICLE RESEARCH, 2016, 19 (01)
[6]   Transition from capacitive coupling to direct charge transfer in asymmetric terahertz plasmonic assemblies [J].
Ahmadivand, Arash ;
Sinha, Raju ;
Gerislioglu, Burak ;
Karabiyik, Mustafa ;
Pala, Nezih ;
Shur, Michael .
OPTICS LETTERS, 2016, 41 (22) :5333-5336
[7]   Plasmonic and metamaterial cloaking:: physical mechanisms and potentials [J].
Alu, Andrea ;
Engheta, Nader .
JOURNAL OF OPTICS A-PURE AND APPLIED OPTICS, 2008, 10 (09)
[8]   Enhanced Gold Nanoparticle Based ELISA for a Breast Cancer Biomarker [J].
Ambrosi, Adriano ;
Airo, Federico ;
Merkoci, Arben .
ANALYTICAL CHEMISTRY, 2010, 82 (03) :1151-1156
[9]   A dynamically reconfigurable Fano metamaterial through graphene tuning for switching and sensing applications [J].
Amin, M. ;
Farhat, M. ;
Bagci, H. .
SCIENTIFIC REPORTS, 2013, 3
[10]   Biosensing with plasmonic nanosensors [J].
Anker, Jeffrey N. ;
Hall, W. Paige ;
Lyandres, Olga ;
Shah, Nilam C. ;
Zhao, Jing ;
Van Duyne, Richard P. .
NATURE MATERIALS, 2008, 7 (06) :442-453