Chemistry of renieramycins. Part 7: Renieramycins T and U, novel renieramycin-ecteinascidin hybrid marine natural products from Thai sponge Xestospongia sp.

被引：39

作者：

Daikuhara, Naomi ^{[1
]}

Tada, Yumiko ^{[1
]}

Yamaki, Sachiyo ^{[1
]}

Charupant, Kornvika ^{[2
]}

Amnuoypol, Surattana ^{[2
]}

Suwanborirux, Khanit ^{[2
]}

Saito, Naoki ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Grad Sch Pharmaceut Sci, Tokyo 2048588, Japan

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Ctr Bioact Nat Prod Marine Organisms & Endophyt F, Bangkok 10330, Thailand

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 29期

基金：

日本学术振兴会;

关键词：

Renieramycin; Ecteinascidin; Cytotoxicity; Marine natural product; Hybrid; PHTHALASCIDIN;

D O I：

10.1016/j.tetlet.2009.05.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new bistetrahydroisoquinoline marine natural products, renieramycins T (1) and U (2), were isolated from the Thai blue sponge Xestospongia sp. and their structures were elucidated by comparing spectral data with those of renieramycin M (3a) and ecteinascidin 770 (4a). These compounds are the first reported examples of novel ecteinascidin-renieramycin hybrid natural products. Renieramycin T (1) showed strong cytotoxicity to several human cancer cell lines. its IC50 values ranging from 4.7 to 98 nM. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4276 / 4278

页数：3

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