Cognitive Impairment in the Septic Brain

被引：41
作者：
Comim, Clarissa M. [3 ]
Constantino, Leandra C. [3 ]
Barichello, Tatiana [2 ]
Streck, Emilio L. [2 ]
Quevedo, Joao [3 ]
Dal-Pizzol, Felipe [1 ,2 ]
机构：
[1] Univ Extremo Catarinense, UNASAU, PPGCS, Lab Fisiopatol Expt,Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil
[2] Univ Extremo Catarinense, Unidade Acad Ciencias Saude, PPGCS, Inst Nacl Ciencia & Tecnol Translac Med, BR-88806000 Criciuma, SC, Brazil
[3] Univ Extremo Catarinense, Unidade Acad Ciencias Saude, PPGCS, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil
来源：
CURRENT NEUROVASCULAR RESEARCH | 2009年 / 6卷 / 03期
关键词：
Cognitive impairment; memory; encephalopathy; sepsis; RESPIRATORY-DISTRESS-SYNDROME; QUALITY-OF-LIFE; VESICULAR ACETYLCHOLINE TRANSPORTER; INTENSIVE-CARE-UNIT; CECAL LIGATION; RAT-BRAIN; CHOLINERGIC INNERVATION; ANTIOXIDANT TREATMENT; PREFRONTAL CORTEX; SEPSIS SURVIVORS;
D O I：
10.2174/156720209788970045
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Sepsis is a major disease entity with important clinical implications. It is associated with a high mortality rate in humans. Recently, several studies have demonstrated that Intensive Care Unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration and/or global loss of cognitive function. The pathogenesis of septic encephalopathy and cognitive impairment are still poorly known and further understanding of these processes is necessary for the development of effective preventive and therapeutic interventions. Here we discuss the clinical presentation and underlying pathophysiology of the encephalopathy and neurobiology of the cognitive impairment associated with sepsis.
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收藏
页码：194 / 203
页数：10
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