Polo-like kinases and the orchestration of cell division

被引：951

作者：

Barr, FA ^{[1
]}

Silljé, HHW ^{[1
]}

Nigg, EA ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Cell Biol, D-82152 Martinsried, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/nrm1401

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis. In agreement with a broad range of proposed functions during cell division, Plks are subject to complex temporal and spatial control. Recent findings are uncovering the mechanisms of Plk regulation, notably their targeting to different cellular structures through interactions with phosphorylated docking proteins. Moreover, information is emerging on the substrate specificity of Plks and the role of individual substrates in M-phase progression.

引用

页码：429 / 440

页数：12

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