Double function at the blood-brain barrier

被引:53
作者
Betsholtz, Christer [1 ,2 ]
机构
[1] Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, S-75185 Uppsala, Sweden
[2] Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden
关键词
SYNCYTIN-2; PERICYTES; MEMBRANE; RECEPTOR; MFSD2A;
D O I
10.1038/nature13339
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Two aspects of the blood–brain barrier — the transport of lipids to the brain and the transport of molecules across cells lining blood vessels — have been shown to be regulated by the same protein, Mfsd2a. See Letters p.503 & p.507
引用
收藏
页码:432 / 433
页数:2
相关论文
共 14 条
[1]   Pericytes regulate the blood-brain barrier [J].
Armulik, Annika ;
Genove, Guillem ;
Mae, Maarja ;
Nisancioglu, Maya H. ;
Wallgard, Elisabet ;
Niaudet, Colin ;
He, Liqun ;
Norlin, Jenny ;
Lindblom, Per ;
Strittmatter, Karin ;
Johansson, Bengt R. ;
Betsholtz, Christer .
NATURE, 2010, 468 (7323) :557-U231
[2]   Mfsd2a is critical for the formation and function of the blood-brain barrier [J].
Ben-Zvi, Ayal ;
Lacoste, Baptiste ;
Kur, Esther ;
Andreone, Benjamin J. ;
Mayshar, Yoav ;
Yan, Han ;
Gu, Chenghua .
NATURE, 2014, 509 (7501) :507-+
[3]   Major Facilitator Superfamily Domain-Containing Protein 2a (MFSD2A) Has Roles in Body Growth, Motor Function, and Lipid Metabolism [J].
Berger, Justin H. ;
Charron, Maureen J. ;
Silver, David L. .
PLOS ONE, 2012, 7 (11)
[4]   Pericytes are required for blood-brain barrier integrity during embryogenesis [J].
Daneman, Richard ;
Zhou, Lu ;
Kebede, Amanuel A. ;
Barres, Ben A. .
NATURE, 2010, 468 (7323) :562-U238
[5]   MEMBRANE ASYMMETRY IN EPITHELIA - IS THE TIGHT JUNCTION A BARRIER TO DIFFUSION IN THE PLASMA-MEMBRANE [J].
DRAGSTEN, PR ;
BLUMENTHAL, R ;
HANDLER, JS .
NATURE, 1981, 294 (5843) :718-722
[6]   A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2 [J].
Esnault, Cecile ;
Priet, Stephane ;
Ribet, David ;
Vernochet, Cecile ;
Bruls, Thomas ;
Lavialle, Christian ;
Weissenbach, Jean ;
Heidmann, Thierry .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17532-17537
[7]   Evolutionarily conserved gene family important for fat storage [J].
Kadereit, Bert ;
Kumar, Pradeep ;
Wang, Wen-Jun ;
Miranda, Diego ;
Snapp, Erik L. ;
Severina, Nadia ;
Torregroza, Ingrid ;
Evans, Todd ;
Silver, David L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (01) :94-99
[8]  
Kidd PM, 2007, ALTERN MED REV, V12, P207
[9]   Ins and Outs of Major Facilitator Superfamily, Antiporters [J].
Law, Christopher J. ;
Maloney, Peter C. ;
Wang, Da-Neng .
ANNUAL REVIEW OF MICROBIOLOGY, 2008, 62 :289-305
[10]   Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid [J].
Nguyen, Long N. ;
Ma, Dongliang ;
Shui, Guanghou ;
Wong, Peiyan ;
Cazenave-Gassiot, Amaury ;
Zhang, Xiaodong ;
Wenk, Markus R. ;
Goh, Eyleen L. K. ;
Silver, David L. .
NATURE, 2014, 509 (7501) :503-+