Influence of the BDNF Val66Met polymorphism on coping response to stress in patients with advanced gastric cancer

被引：20
作者：
Koh, Min Jung [1 ,2 ]
Jeung, Hei-Cheul [3 ]
Namkoong, Kee [1 ,2 ]
Chung, Hyun Cheol [4 ]
Kang, Jee In [1 ,2 ]
机构：
[1] Yonsei Univ, Coll Med, Dept Psychiat, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Inst Behav Sci Med, Seoul 120752, South Korea
[3] Yonsei Univ, Coll Med, Yonsei Canc Res Inst,Yonsei Canc Ctr, Dept Internal Med,Gangnam Severance Hosp,Div Onco, Seoul 120752, South Korea
[4] Yonsei Univ, Coll Med, Dept Internal Med, Div Oncol,Severance Hosp,Yonsei Canc Ctr, Seoul 120752, South Korea
来源：
JOURNAL OF PSYCHOSOMATIC RESEARCH | 2014年 / 77卷 / 01期
关键词：
Anxious Preoccupation; BDNF; Cancer; Coping; Genetic association study; Psychosomatics; POPULATION-BASED COHORT; MENTAL ADJUSTMENT; BREAST-CANCER; PSYCHOLOGICAL RESPONSE; PSYCHIATRIC-DISORDERS; MINI-MAC; ANXIETY; DEPRESSION; PERSONALITY; SURVIVAL;
D O I：
10.1016/j.jpsychores.2014.04.008
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objective: Coping with cancer is an important determinant of psychological morbidity, quality of life, and treatment adherence in cancer patients. The aim of this study was to elucidate the association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and coping response to stress in patients diagnosed with advanced gastric cancer. Methods: Ninety-one subjects (60 males, 31 females) recently diagnosed with advanced gastric cancer were recruited. Coping style and distress level were examined using the Mini-Mental Adjustment to Cancer (Mini-MAC) scale and Hospital Anxiety and Depression Scale, and genotyping was evaluated. To examine the temporal stability of the Mini-MAC scores, a 6-week follow-up evaluation was conducted in 72 patients, after completion of two chemotherapy cycles. Results: Coping style to cancer significantly differed between the Met carriers of BDNF Val66Met and the Val/Val homozygotes. The Met carriers were significantly more anxious than the Val/Val homozygotes. Conclusion: The present findings suggest that the BDNF Val66Met polymorphism may be involved in individual coping responses to cancer. The Met allele of BDNF Val66Met may be predictive of an anxious coping style in patients with advanced cancer. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：76 / 80
页数：5
相关论文
共 40 条
[1]   Genetic and environmental influences on coping styles: A twin study [J].
Busjahn, A ;
Faulhaber, HD ;
Freier, K ;
Luft, FC .
PSYCHOSOMATIC MEDICINE, 1999, 61 (04) :469-475
[2]  
Calabrese F., 2009, PSYCHONEUROENDOCRINO, V345, pS208, DOI DOI 10.1016/J.PSYNEUEN.2009.05.014
[3]   Personality and Coping [J].
Carver, Charles S. ;
Connor-Smith, Jennifer .
ANNUAL REVIEW OF PSYCHOLOGY, 2010, 61 :679-704
[4]   Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior [J].
Chen, Zhe-Yu ;
Jing, Deqiang ;
Bath, Kevin G. ;
Ieraci, Alessandro ;
Khan, Tanvir ;
Siao, Chia-Jen ;
Herrera, Daniel G. ;
Toth, Miklos ;
Yang, Chingwen ;
McEwen, Bruce S. ;
Hempstead, Barbara L. ;
Lee, Francis S. .
SCIENCE, 2006, 314 (5796) :140-143
[5]   BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults [J].
Colzato, Lorenza S. ;
van der Does, A. J. Willem ;
Kouwenhoven, Coen ;
Elzinga, Bernet M. ;
Hommel, Bernhard .
PSYCHONEUROENDOCRINOLOGY, 2011, 36 (10) :1562-1569
[6]   THE PREVALENCE OF PSYCHIATRIC-DISORDERS AMONG CANCER-PATIENTS [J].
DEROGATIS, LR ;
MORROW, GR ;
FETTING, J ;
PENMAN, D ;
PIASETSKY, S ;
SCHMALE, AM ;
HENRICHS, M ;
CARNICKE, CLM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1983, 249 (06) :751-757
[7]   Impact of the BDNF Val66Met Polymorphism on Cognition: Implications for Behavioral Genetics [J].
Dincheva, Iva ;
Glatt, Charles E. ;
Lee, Francis S. .
NEUROSCIENTIST, 2012, 18 (05) :439-451
[8]   The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function [J].
Egan, MF ;
Kojima, M ;
Callicott, JH ;
Goldberg, TE ;
Kolachana, BS ;
Bertolino, A ;
Zaitsev, E ;
Gold, B ;
Goldman, D ;
Dean, M ;
Lu, B ;
Weinberger, DR .
CELL, 2003, 112 (02) :257-269
[9]   G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences [J].
Faul, Franz ;
Erdfelder, Edgar ;
Lang, Albert-Georg ;
Buchner, Axel .
BEHAVIOR RESEARCH METHODS, 2007, 39 (02) :175-191
[10]   Personality and coping traits: A joint factor analysis [J].
Ferguson, E .
BRITISH JOURNAL OF HEALTH PSYCHOLOGY, 2001, 6 :311-325
1234