DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo

被引：0

作者：

Ramirez-Alcantara, Veronica ^{[1
]}

Keeton, Adam B. ^{[1
]}

Zhu, Bing ^{[1
]}

Lee, Kevin J. ^{[1
]}

Canzoneri, Joshua ^{[2
]}

Lindsey, Ashley S. ^{[1
]}

Barnes, Luciana Madeira da Silva ^{[1
]}

Berry, Kristy ^{[1
]}

Valiyaveettil, Jacob ^{[1
]}

Chen, Xi ^{[1
]}

Boyd, Michael R. ^{[2
]}

Piazza, Gary ^{[1
]}

机构：

[1] Univ S Alabama, Mitchell Canc Inst, Drug Discovery Res Ctr, Mobile, AL 36688 USA

[2] Anticanc Dev Therapeut Pharmaceut Inc, Orange Beach, AL USA

来源：

CANCER RESEARCH | 2017年 / 77卷

关键词：

D O I：

10.1158/1538-7445.CRC16-B23

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B23

引用

页数：2

共 50 条

[1] Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells
Zhu, Bing
Chen, Xi
Valiyaveettil, Jacob
Canzoneri, Joshua
Lee, Kevin
Saville, Kate
Berry, Kristy
Barnes, Luciana
Maddox, Tyler
Lindsey, Ashley
Ward, Antonio
Ramirez-Alcantara, Veronica
Keeton, Adam
Boyd, Michael
Piazza, Gary
CANCER RESEARCH, 2017, 77
[2] Novel RAS inhibitors DC070-547 and ADT-006 potently and selectively inhibit the growth of pancreatic tumor cells harboring constitutively activated RAS by blocking RAS-effector binding and signaling
Mattox, Tyler E.
Lee, Kevin J.
Chen, Xi
Valiyaveettil, Jacob
da Silva, Luciana Madeira
Lindsey, Ashley S.
Keeton, Adam B.
Zhu, Bing
Boyd, Michael
Piazza, Gary A.
CANCER RESEARCH, 2017, 77
[3] A novel RAS inhibitor, MCI-062, inhibits colon tumor growth in vivo and activates antitumor immunity
Keeton, Adam B.
Ward, Antonio
Chen, Xi
Valiyaveettil, Jacob
Zhu, Bing
Ramirez-Alcantara, Veronica
Maxuitenko, Yulia
Berry, Kristy
Mattox, Tyler E.
Boyd, Michael R.
Piazza, Gary A.
CANCER RESEARCH, 2019, 79 (13)
[4] HDAC6 Inhibitor C1A Synergizes with BEZ-235 in Colon Cancer Cells in Vitro and Potently Inhibits Tumor Growth in Vivo
Kaliszczak, M.
Trousil, S.
Aberg, O.
Perumal, M.
Nguyen, Q. D.
Aboagye, E. O.
EUROPEAN JOURNAL OF CANCER, 2012, 48 : 162 - 162
[5] Novel RAS inhibitor, MCI-062, potently and selectively inhibits the growth of KRAS mutant pancreatic tumor cells by blocking GTP loading of RAS
Mattox, Tyler E.
Chen, Xi
Valiyaveettil, Jacob
Maxuitenko, Yulia
Zhu, Bing
Ward, Antonio
Ramirez-Alcantara, Veronica
Berry, Kristy
Boyd, Michael
Keeton, Adam
Piazza, Gary A.
CANCER RESEARCH, 2019, 79 (13)
[6] A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding
Zhu, Bing
Chen, Xi
Ramirez-Alcantara, Veronica
Lee, Kevin
Valiyaveettil, Jacob
Canzoneri, Joshua
Sigler, Sara
Berry, Kristy
Lindsey, Ashley
Keeton, Adam
Boyd, Michael R.
Piazza, Gary A.
CANCER RESEARCH, 2016, 76
[7] THE RAS INHIBITOR FARNESYLTHIOSALICYLIC ACID INHIBITS THE GROWTH OF HEPATOCARCINOMA CELL LINES IN VITRO AND IN VIVO
Charette, N.
Lannoy, V.
De Saeger, C.
Leclercq, I.
Horsmans, Y.
Staerkel, R.
JOURNAL OF HEPATOLOGY, 2009, 50 : S189 - S189
[8] Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models
Wu, Xiao Yu
Xu, Hao
Wu, Zhen Feng
Chen, Che
Liu, Jia Yun
Wu, Guan Nan
Yao, Xue Quan
Liu, Fu Kun
Li, Gang
Shen, Liang
ONCOTARGET, 2015, 6 (42) : 44563 - 44578
[9] SRI 21009: A novel sulindac derivative that potently inhibits colon tumor cell growth without inhibiting cyclooxygenases
Piazza, Gary
Keeton, Adam
Gary, Bernard
Thaiparambil, Jose
Tinsley, Heather
Mathew, Bini
Gilbert, Karen
Coward, Lori
Roy, Anshu
Qu, Zhican
Gorman, Greg
Maxuitenko, Yulia
Reynolds, Robert
CANCER RESEARCH, 2008, 68 (09)
[10] Chloroquine Inhibits Colon Cancer Cell Growth In Vitro and Tumor Growth In Vivo via Induction of Apoptosis
Zheng, Yuzhu
Zhao, Ying-Lan
Deng, Xiaoqiang
Yang, Shengyong
Mao, Yongqiu
Li, Zhengguang
Jiang, Peidu
Zhao, Xia
Wei, Yuquan
CANCER INVESTIGATION, 2009, 27 (03) : 286 - 292

← 1 2 3 4 5 →