Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts

被引：18

作者：

Cichy, J

RoseJohn, S

Pryjma, J

Travis, J

机构：

[1] UNIV GEORGIA,DEPT BIOCHEM & MOL BIOL,ATHENS,GA 30602

[2] JAGIELLONIAN UNIV,INST MOL BIOL,DEPT MICROBIOL & IMMUNOL,PL-31120 KRAKOW,POLAND

[3] UNIV MAINZ,DEPT MED,D-55101 MAINZ,GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 227卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.1507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study the ability of soluble interleukin-6 receptor (sIL-6R) to stimulate interleukin-6 (IL-B) synthesis in human fibroblasts is described. It was found that sIL-6R, in combination with endogenous or exogenous IL-6, markedly upregulated IL-6 synthesis. These data suggest that increased IL-6 production after stimulation by either interleukin-l or tumor necrosis factor-alpha would result in complex formation with sIL-6R, rapid uptake, and further synthesis of this cytokine. Furthermore, it would explain the decrease in sIL-6R plasma levels observed in patients suffering, from sepsis. (C) 1996 Academic Press, Inc.

引用

收藏

页码：318 / 321

页数：4

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