Phytochemical and larvicidal studies on Stemona curtisii:: Structure of a new pyrido[1,2-α]azepine Stemona alkaloid

被引：58

作者：

Mungkornasawakul, P

Pyne, SG ^{[1
]}

Jatisatienr, A

Supyen, D

Jatisatienr, C

Lie, W

Ung, AT

Skelton, BW

White, AH

机构：

[1] Chiang Mai Univ, Div Environm Sci, Chiang Mai 50202, Thailand

[2] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia

[3] Chiang Mai Univ, Dept Biol, Chiang Mai 50202, Thailand

[4] Chiang Mai Univ, Dept Chem, Chiang Mai 50202, Thailand

[5] Univ Western Australia, Dept Chem, Crawley, WA 6009, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 04期

关键词：

D O I：

10.1021/np034066u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new pentacyclic Stemona alkaloid, stemocurtisinol (3), with a pyrido[1,2-a]azepine A,B-ring system, and the known pyrrolo[1,2-a]azepine alkaloid oxyprotostemonine (4) have been isolated from a root extract of S. curtisii. The structure and relative stereochemistry of stemocurtisinol was determined by spectral data interpretation and X-ray crystallography. This compound is a diastereoisomer of oxystemokerrin and has the opposite configuration at C-4 and C-19. The individual alkaloid components showed significant larvicidal activity (IC50 4-39 ppm) on mosquito larvae (Anopheles minimus HO).

引用

页码：675 / 677

页数：3

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