Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp AJ9571

被引：16

作者：

Murakami, Ryo ^{[1
]}

Shinozaki, Junko ^{[2
]}

Kajiura, Takayuki ^{[2
]}

Kozone, Ikuko ^{[3
]}

Takagi, Motoki ^{[3
]}

Shin-Ya, Kazuo ^{[4
]}

Seto, Haruo ^{[5
]}

Hayakawa, Yoichi ^{[6
]}

机构：

[1] Daiichi Sankyo Co Ltd, Exploratory Res Labs 2, Edogawa Ku, Tokyo 1348630, Japan

[2] Ajinomoto Co Inc, Pharmaceut Res Labs, Kawasaki, Kanagawa, Japan

[3] JBIC, BIRC, Tokyo, Japan

[4] Natl Inst Adv Ind Sci & Technol, Tokyo, Japan

[5] Tokyo Univ Agr, Fac Appl Biosci, Tokyo, Japan

[6] Tokyo Univ Sci, Fac Pharmaceut Sci, Chiba, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2009年 / 62卷 / 03期

关键词：

ammocidin; cytotoxic; macrolide; Saccharothrix; RAS-DEPENDENT CELLS; APOPTOSIS INDUCER;

D O I：

10.1038/ja.2008.23

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ammocidins B, C and D were isolated from the culture broth of Saccharothrix sp. AJ9571, an ammocidin A-producing strain. Their structures were determined by a detailed spectroscopic analysis and by a comparison of their NMR data with those of ammocidin A. Ammocidins A and B showed potent anti-proliferative activities against human cancer cell lines.

引用

页码：123 / 127

页数：5

共 2 条

[1] Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp -: II.: Physico-chemical properties and structure elucidation [J].

Murakami, R ;

Tomikawa, T ;

Shin-Ya, K ;

Shinozaki, J ;

Kajiura, T ;

Seto, H ;

Hayakawa, Y .

JOURNAL OF ANTIBIOTICS, 2001, 54 (09) :714-717

[2] Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp.: I.: Production, isolation and biological activity [J].

Murakami, R ;

Tomikawa, T ;

Shin-Ya, K ;

Shinozaki, J ;

Kajiura, T ;

Kinoshita, T ;

Miyajima, A ;

Seto, H ;

Hayakawa, Y .

JOURNAL OF ANTIBIOTICS, 2001, 54 (09) :710-713

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