Current status of xenotransplantation and prospects for clinical application

被引：102

作者：

Pierson, Richard N., III ^{[1
]}

Dorling, Anthony ^{[2
]}

Ayares, David ^{[3
,4
]}

Rees, Michael A. ^{[5
]}

Seebach, Joerg D. ^{[6
,7
]}

Fishman, Jay A. ^{[8
]}

Hering, Bernhard J. ^{[9
]}

Cooper, David K. C. ^{[10
]}

机构：

[1] Univ Maryland, Div Cardiac Surg, Dept Surg, Baltimore VAMC, Baltimore, MD 21201 USA

[2] Univ London Imperial Coll Sci Technol & Med, Dept Immunol, London, England

[3] Revivicor Inc, Blacksburg, VA USA

[4] Revivicor Inc, Pittsburgh, PA USA

[5] Univ Toledo, Dept Urol, Ctr Med, Toledo, OH 43606 USA

[6] Univ Hosp Geneva, Serv Clin Immunol & Allergol, Dept Internal Med, Geneva, Switzerland

[7] Fac Med, Geneva, Switzerland

[8] Massachusetts Gen Hosp, Dept Med, Transplant Infect Dis & Compromised Host Program, Boston, MA 02114 USA

[9] Univ Minnesota, Dept Surg, Diabet Inst Immunol & Transplantat, Minneapolis, MN 55455 USA

[10] Univ Pittsburgh, Dept Surg, Thomas E Starzl Transplantat Inst, Pittsburgh, PA USA

来源：

XENOTRANSPLANTATION | 2009年 / 16卷 / 05期

基金：

瑞士国家科学基金会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

antibody-mediated rejection; coagulation; genetic engineering; pig; pancreatic islets; Pig; xenotransplantation; alpha; 1; 3-galactosyltransferase gene-knockout; ACUTE VASCULAR REJECTION; HEMATOPOIETIC-CELL TRANSPLANTATION; PORCINE ENDOGENOUS RETROVIRUS; HUMAN NK CYTOTOXICITY; NATURAL-KILLER-CELL; LONG-TERM SURVIVAL; GENE-KNOCKOUT PIGS; ENDOTHELIAL-CELLS; T-CELL; XENOGRAFT REJECTION;

D O I：

10.1111/j.1399-3089.2009.00534.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Xenotransplantation is one promising approach to bridge the gap between available human cells, tissues, and organs and the needs of patients with diabetes or end-stage organ failure. Based on recent progress using genetically modified source pigs, improving results with conventional and experimental immunosuppression, and expanded understanding of residual physiologic hurdles, xenotransplantation appears likely to be evaluated in clinical trials in the near future for some select applications. This review offers a comprehensive overview of known mechanisms of xenograft injury, a contemporary assessment of preclinical progress and residual barriers, and our opinions regarding where breakthroughs are likely to occur.

引用

页码：263 / 280

页数：18

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