Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

被引：1180

作者：

Zhang, Chen ^{[1
]}

Bu, Wenbo ^{[1
]}

Ni, Dalong ^{[1
]}

Zhang, Shenjian ^{[2
]}

Li, Qing ^{[1
]}

Yao, Zhenwei ^{[3
]}

Zhang, Jiawen ^{[3
]}

Yao, Heliang ^{[1
]}

Wang, Zheng ^{[1
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Fudan Univ, Dept Radiol, Shanghai Canc Hosp, Shanghai 200032, Peoples R China

[3] Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai 200040, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 06期

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

antitumor agents; cancer; Fenton reaction; iron nanoparticles; magnetic resonance imaging; PHOTODYNAMIC THERAPY; HYDROGEN-PEROXIDE; DRUG-RELEASE; NANOPARTICLES; PH; T-1;

D O I：

10.1002/anie.201510031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H2O2 in a tumor microenvironment: Ionization of the AFeNPs enables on-demand ferrous ion release in the tumor, and subsequent H2O2 disproportionation leads to efficient (OH)-O-. generation. The endogenous stimuli-responsive (OH)-O-. generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.

引用

页码：2101 / 2106

页数：6

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