Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression

被引：19

作者：

Li, Huidan ^{[1
,2
]}

Sun, Xiaoxuan ^{[3
]}

Zhang, Jie ^{[1
,2
]}

Sun, Yue ^{[1
,2
]}

Huo, Rongfen ^{[1
,2
]}

Li, Haichuan ^{[1
,2
,4
]}

Zhai, Tianhang ^{[1
,2
]}

Shen, Baihua ^{[1
,2
]}

Zhang, Miaojia ^{[3
]}

Li, Ningli ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, 280 South Chong Qing Rd, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Dept Immunol & Microbiol, 280 South Chong Qing Rd, Shanghai 200025, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Rheumatol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[4] Matern & Child Hlth Hosp, Shanghai, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2016年 / 30卷

基金：

中国国家自然科学基金;

关键词：

Paeoniflorin; Sjogren's syndrome; Cyr61/CCN1; Epithelial cells; FIBROBLAST-LIKE SYNOVIOCYTES; TOTAL GLUCOSIDES; DENDRITIC CELLS; EPITHELIAL-CELLS; PEONY; PATHOGENESIS; INFILTRATION; LESIONS; DIFFERENTIATION; MANIFESTATIONS;

D O I：

10.1016/j.intimp.2015.11.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Paeoniflorin (PF), an active compound extracted from Paeony root, has been used in therapy of autoimmune diseases with effective clinical efficiency and higher safety. Sjogren's syndrome (SS) is a chronic, systemic, immune mediated inflammatory disease. In this study, we demonstrated that novel pro-inflammatory factor Cyr61/CCN1 was up-regulated in epithelial cells of salivary glands of primary SS patients and submandibular gland autoantigen-induced experimental SS mice. Blocking Cyr61 expression with special monoclonal antibody improved saliva secretion by ameliorating inflammatory infiltration and cytokines production in vivo. Furthermore, we showed that PF could alleviate inflammation by down-regulating Cyr61 expression in experimental SS mice. In conclusion, our new findings revealed for the first time that Cyr61 involves the pathogenesis of primary SS and PF alleviates SS-like symptoms associated with inhibiting Cyr61 expression, providing new insights into the potential molecular mechanism of PF in primary SS treatment. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：27 / 35

页数：9

共 44 条

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