Two-year efficacy and safety of Simvastatin 80 mg in familial hypercholesterolemia (The examination of probands and relatives in statin studies with familial hypercholesterolemia [ExPRESS FH])

被引：23
|
作者：
Nolting, PRWD
Buirma, RJA
Hutten, BA
Kastelein, JJP
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands
[3] Merck Sharp & Dohme Ltd, Clin Res, Haarlem, Netherlands
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 90卷 / 02期
关键词：
D O I：
10.1016/S0002-9149(02)02449-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
High-dose (80 mg) simvastatin is efficacious in both reducing low-density lipoprotein cholesterol (-48%) and triglyceride (-26%) levels and in elevating high-density lipoprotein cholesterol (+ 13%) levels in a large cohort of patients with familial hypercholesterolemia. No tachyphylaxis was seen during a 2-year treatment period, and therapy with simvastatin 80 mg was well tolerated.
引用
收藏
页码：181 / +
页数：5
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