Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy

被引：29

作者：

Benamar, Houari ^{[1
,2
]}

Tomassini, Lamberto ^{[3
]}

Venditti, Alessandro ^{[3
]}

Marouf, Abderrazak ^{[1
,4
]}

Bennaceur, Malika ^{[1
,5
]}

Serafini, Mauro ^{[3
]}

Nicoletti, Marcello ^{[3
]}

机构：

[1] Univ Oran 1 Ahmed Benbella, Fac Nat Sci & Life, Dept Biol, Lab Biochem & Nat Prod, Oran, Algeria

[2] Univ Mostaganem Abdelhamid Ibn Badis, Fac Nat Sci & Life, Dept Biol, Mostaganem, Algeria

[3] Univ Sapienza, Dept Environm Biol, Rome, Italy

[4] Ctr Univ Naama, Inst Sci & Technol, Dept Nat Sci & Life, Naama, Algeria

[5] Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Lab Res Arid Areas, Algiers, Algeria

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 11期

关键词：

Boraginaceae; Echium confusum; pyrrolizidine alkaloids; 7-O-angeloyllycopsamine N-oxide; anti-AChE activity; CHROMATOGRAPHY; BORAGINACEAE; AMOENUM; EXTRACT;

D O I：

10.1080/14786419.2016.1242000

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four pyrrolizidine alkaloids, namely 7-O-angeloyllycopsamine N-oxide 1, echimidine N-oxide 2, echimidine 3 and 7-O-angeloylretronecine 4, were isolated for the first time from the whole plant ethanolic extract of Echium confusum Coincy, through bioassay-guided approach. Their structures were determined by spectroscopic means. All the isolates compounds showed moderate activities in inhibiting AChE, with IC50 0.276-0.769. [GRAPHICS]

引用

页码：1277 / 1285

页数：9

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