Copper-Promoted Site-Selective Acyloxylation of Unactivated C(sp3)-H Bonds

被引：48
|
作者：
Wu, Xuesong [1 ]
Zhao, Yan [1 ,2 ]
Ge, Haibo [1 ,2 ]
机构：
[1] Indiana Univ Purdue Univ, Dept Chem & Chem Biol, Indianapolis, IN 46202 USA
[2] Nanjing Univ, Inst Chem & BioMed Sci, Nanjing 210093, Jiangsu, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 10期
关键词：
acyloxylation; CH activation; copper; site-selective; unactivated sp(3) carbons; CATALYZED INTRAMOLECULAR AMINATION; C-H ACTIVATION; COUPLING REACTIONS; DIRECTING GROUP; PALLADIUM; FUNCTIONALIZATION; ARYLATION; ARENE; COMPLEXES; ALKYLATION;
D O I：
10.1002/asia.201402510
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The site-selective acyloxylation of aliphatic amides was achieved via a copper-promoted C(sp(3))H bond functionalization process directed by a bidentate ligand. The reaction showed a great preference for activating CH bonds of -methyl groups over those of -methyl and unactivated methylene groups.
引用
收藏
页码：2736 / 2739
页数：4
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