Psoriasis and comorbid diseases Epidemiology

被引：871

作者：

Takeshita, Junko ^{[1
,2
]}

Grewal, Sungat ^{[1
]}

Langan, Sinead M. ^{[4
,5
]}

Mehta, Nehal N. ^{[6
]}

Ogdie, Alexis ^{[2
,3
]}

Van Voorhees, Abby S. ^{[7
]}

Gelfand, Joel M. ^{[1
,2
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA

[2] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Div Rheumatol, Philadelphia, PA 19104 USA

[4] London Sch Hyg & Trop Med, London, England

[5] St Johns Inst Dermatol, London, England

[6] NHLBI, Bldg 10, Bethesda, MD 20892 USA

[7] Eastern Virginia Med Sch, Dept Dermatol, Norfolk, VA 23501 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2017年 / 76卷 / 03期

关键词：

cardiovascular disease; chronic kidney disease; comorbidities; Crohn's disease; depression; metabolic syndrome; nonalcoholic fatty liver disease; psoriasis; psoriatic arthritis; lymphoma; infection; POPULATION-BASED-COHORT; CARDIOVASCULAR RISK STRENGTH; CHOLESTEROL EFFLUX CAPACITY; PLATELET-DERIVED MICROPARTICLES; CAUSE-SPECIFIC MORTALITY; STRESSFUL LIFE EVENTS; HONG-KONG CHINESE; GENOME-WIDE SCAN; METABOLIC SYNDROME; US WOMEN;

D O I：

10.1016/j.jaad.2016.07.064

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known comorbidity of psoriasis. A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders. The pathogenesis of comorbid disease in patients with psoriasis remains unknown; however, shared inflammatory pathways, cellularmediators, genetic susceptibility, and common risk factors are hypothesized to be contributing elements. As additional psoriasis comorbidities continue to emerge, education of health care providers is essential to ensuring comprehensive medical care for patients with psoriasis.

引用

页码：377 / 390

页数：14

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