Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition

被引：31

作者：

Paramashivappa, R ^{[1
]}

Kumar, PP ^{[1
]}

Rao, PVS ^{[1
]}

Rao, AS ^{[1
]}

机构：

[1] Vittal Mallya Sci Res Fdn, Bangalore 560004, Karnataka, India

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2002年 / 50卷 / 26期

关键词：

Anacardic acid; cashew nut shell liquid; sildenafil; PDE5; inhibitor; erectile dysfunction;

D O I：

10.1021/jf0258050

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Anacardic acid (6-pentadecylsalicylic acid), a major component of cashew nut shell liquid, consists of a heterogeneous mixture of monoenes, dienes, and trienes. The enes mixture of anacardic acid was hydrogenated to a saturated compound. Using saturated anacardic acid as a starting material, analogues of sildenafil [a potent phosphodiesterase-5 (PDE5) inhibitor and an orally active drug for the treatment of erectile dysfunction] were synthesized, to observe the effect of the pentadecyl side chain on PDE5 inhibition. The synthesized compounds were characterized by spectral studies and tested for PDE5 inhibition, and the results were compared With those obtained with sildenafil.

引用

页码：7709 / 7713

页数：5

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