Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N-methyl-D-aspartate receptor in anxiety: a literature review

被引：5
|
作者：
da Cruz, Julia Niehues [1 ]
Dal Magro, Debora Delwing [2 ]
de Lima, Daniela Delwing [3 ]
Pereira da Cruz, Jose Geraldo [2 ]
机构：
[1] Inst Dante Pazzanese Cardiol, Sao Paulo, SP, Brazil
[2] Univ Reg Blumenau, Blumenau, SC, Brazil
[3] Univ Regiao Joinville, Joinville, SC, Brazil
来源：
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 53卷 / 01期
关键词：
Anxiolytic effects; Membrane/lipid rafts; N-methyl-D-aspartate; Simvastatin; LONG-TERM POTENTIATION; ELEVATED PLUS-MAZE; NMDA RECEPTOR; LIPID RAFTS; SYNAPTIC-TRANSMISSION; GLUTAMATE RECEPTORS; UP-REGULATION; METABOLISM; NEURONS; STATINS;
D O I：
10.1590/s2175-97902017000116102
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs and, in turn, decrease NMDA-mediated anxiety. This hypothesis will contribute to understanding the critical roles of simvastatin in treating anxiety via the NMDA receptor.
引用
收藏
页数：15
相关论文
共 50 条
  • [1] Specific role of calpain-1 associated to N-methyl-D-aspartate receptor in lipid rafts microdomains
    Pellegrini, M.
    Averna, M.
    Pedrazzi, M.
    De Tullio, R.
    Salamino, F.
    Melloni, E.
    FEBS JOURNAL, 2016, 283 : 187 - 187
  • [2] Not Your Average Seizure: A Case of N-Methyl-D-Aspartate Receptor Encephalitis and Review of Literature
    Alkayali, Talal
    Bell, Stephen
    Bass, Caitlin
    Lattanzio, Natalia
    Kraitman, Natan
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (07)
  • [3] ROLE OF LIPID SOLUBILITY IN THE INTERACTION OF DRUGS WITH THE N-METHYL-D-ASPARTATE RECEPTOR
    REYNOLDS, IJ
    RUSH, EA
    SYNAPSE, 1990, 5 (01) : 71 - 76
  • [4] Activation of neuronal N-methyl-D-aspartate receptor channels by lipid emulsions
    Weigt, HU
    Georgieff, M
    Beyer, C
    Föhr, KF
    ANESTHESIA AND ANALGESIA, 2002, 94 (02): : 331 - 337
  • [5] Bortezomib in N-methyl-d-aspartate receptor encephalitis: A systematic review
    Dinoto, Alessandro
    Cheli, Marta
    Sartori, Arianna
    Bratina, Alessio
    Manganotti, Paolo
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2021, 429 : 18 - 18
  • [6] N-methyl-D-aspartate (NMDA) receptor antagonists for treatment of catatonia in adults: Narrative review
    Lee, Jeong Hoo
    Suzuki, Joji
    GENERAL HOSPITAL PSYCHIATRY, 2024, 91 : 60 - 65
  • [7] Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review
    Iadarola, Nicolas D.
    Niciu, Mark J.
    Richards, Erica M.
    Vande Voort, Jennifer L.
    Ballard, Elizabeth D.
    Lundin, Nancy B.
    Nugent, Allison C.
    Machado-Vieira, Rodrigo
    Zarate, Carlos A., Jr.
    THERAPEUTIC ADVANCES IN CHRONIC DISEASE, 2015, 6 (03) : 97 - 114
  • [8] Electroconvulsive therapy in N-methyl-D-aspartate receptor encephalitis: A retrospective cohort and scoping review of literature
    Wright, Melissa A.
    Guasp, Mar
    Lachner, Christian
    Day, Gregory S.
    Gombolay, Grace
    Titulaer, Maarten J.
    Clardy, Stacey L.
    JOURNAL OF NEUROIMMUNOLOGY, 2024, 392
  • [9] Activation of N-methyl-D-aspartate receptor regulates insulin sensitivity and lipid metabolism
    Huang, Xiao-Ting
    Yang, Jun-Xiao
    Wang, Zun
    Zhang, Chen-Yu
    Luo, Zi-Qiang
    Liu, Wei
    Tang, Si-Yuan
    THERANOSTICS, 2021, 11 (05): : 2247 - 2262
  • [10] N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST AND ASD: A SYSTEMATIC REVIEW
    Gupta, Nihit
    Gupta, Mayank
    Emereonye, Kelechi N.
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2023, 62 (10): : S296 - S296
12345