Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1

被引：22

作者：

Zhang, Fan ^{[1
]}

Gong, Zihua ^{[1
]}

机构：

[1] Cleveland Clin, Dept Canc Biol, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2021年 / 22卷 / 01期

关键词：

P53-binding protein 1 (53BP1); DNA double-strand break (DSB); Non-homologous end-joining (NHEJ); Homologous recombination (HR); Poly(ADP-ribose) polymerase inhibitor (PARPi); HOMOLOGOUS RECOMBINATION; STRUCTURAL BASIS; CELLULAR-RESPONSE; DAMAGE-RESPONSE; END; RESECTION; UBIQUITIN; BINDING; COMPLEX; DOMAIN;

D O I：

10.1631/jzus.B2000306

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maintenance of cellular homeostasis and genome integrity is a critical responsibility of DNA double-strand break (DSB) signaling. P53-binding protein 1 (53BP1) plays a critical role in coordinating the DSB repair pathway choice and promotes the non-homologous end-joining (NHEJ)-mediated DSB repair pathway that rejoins DSB ends. New insights have been gained into a basic molecular mechanism that is involved in 53BP1 recruitment to the DNA lesion and how 53BP1 then recruits the DNA break-responsive effectors that promote NHEJ-mediated DSB repair while inhibiting homologous recombination (HR) signaling. This review focuses on the up- and downstream pathways of 53BP1 and how 53BP1 promotes NHEJ-mediated DSB repair, which in turn promotes the sensitivity of poly(ADP-ribose) polymerase inhibitor (PARPi) in BRCA1-deficient cancers and consequently provides an avenue for improving cancer therapy strategies.

引用

页码：38 / 46

页数：9

共 73 条

[1] Checkpoint signalling: focusing on 53BP1 [J].

Abraham, RT .

NATURE CELL BIOLOGY, 2002, 4 (12) :E277-E279

[2] Tying the loose ends together in DNA double strand break repair with 53BP1 [J].

Adams, Melissa M. ;

Carpenter, Phillip B. .

CELL DIVISION, 2006, 1 (1)

[3] Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage [J].

Anderson, L ;

Henderson, C ;

Adachi, Y .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (05) :1719-1729

[4] The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks [J].

Bekker-Jensen, Simon ;

Mailand, Niels .

FEBS LETTERS, 2011, 585 (18) :2914-2919

[5] Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage [J].

Bin Wang ;

Elledge, Stephen J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (52) :20759-20763

[6] MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection [J].

Boersma, Vera ;

Moatti, Nathalie ;

Segura-Bayona, Sandra ;

Peuscher, Marieke H. ;

van der Torre, Jaco ;

Wevers, Brigitte A. ;

Orthwein, Alexandre ;

Durocher, Daniel ;

Jacobs, Jacqueline J. L. .

NATURE, 2015, 521 (7553) :537-U291

[7] Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1 [J].

Bothmer, Anne ;

Robbiani, Davide F. ;

Di Virgilio, Michela ;

Bunting, Samuel F. ;

Klein, Isaac A. ;

Feldhahn, Niklas ;

Barlow, Jacqueline ;

Chen, Hua-Tang ;

Bosque, David ;

Callen, Elsa ;

Nussenzweig, Andre ;

Nussenzweig, Michel C. .

MOLECULAR CELL, 2011, 42 (03) :319-329

[8] Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair [J].

Botuyan, Maria Victoria ;

Lee, Joseph ;

Ward, Irene M. ;

Kim, Ja-Eun ;

Thompson, James R. ;

Chen, Junjie ;

Mer, Georges .

CELL, 2006, 127 (07) :1361-1373

[9] Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein [J].

Botuyan, Maria Victoria ;

Cui, Gaofeng ;

Drane, Pascal ;

Oliveira, Catarina ;

Detappe, Alexandre ;

Brault, Marie Eve ;

Parnandi, Nishita ;

Chaubey, Shweta ;

Thompson, James R. ;

Bragantini, Benoit ;

Zhao, Debiao ;

Chapman, J. Ross ;

Chowdhury, Dipanjan ;

Mer, Georges .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 25 (07) :591-+

[10] 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers [J].

Bouwman, Peter ;

Aly, Amal ;

Escandell, Jose M. ;

Pieterse, Mark ;

Bartkova, Jirina ;

van der Gulden, Hanneke ;

Hiddingh, Sanne ;

Thanasoula, Maria ;

Kulkarni, Atul ;

Yang, Qifeng ;

Haffty, Bruce G. ;

Tommiska, Johanna ;

Blomqvist, Carl ;

Drapkin, Ronny ;

Adams, David J. ;

Nevanlinna, Heli ;

Bartek, Jiri ;

Tarsounas, Madalena ;

Ganesan, Shridar ;

Jonkers, Jos .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (06) :688-U56

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