Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

被引：34

作者：

Chen, Sijie ^{[1
,2
]}

Hong, Yuning ^{[1
,2
]}

Liu, Jianzhao ^{[1
,2
]}

Tseng, Nai-Wen ^{[1
,2
]}

Liu, Yang ^{[1
,2
]}

Zhao, Engui ^{[1
,2
]}

Lam, Jacky Wing Yip ^{[1
,2
]}

Tang, Ben Zhong ^{[1
,2
,3
,4
]}

机构：

[1] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Div Life Sci, Inst Adv Study,Dept Chem,Div Biomed Engn, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Kowloon, Hong Kong, Peoples R China

[3] S China Univ Technol, State Key Lab Luminescent Mat & Device, SCUT HKUST Joint Res Lab, Guangdong Innovat Res Team, Guangzhou 510640, Guangdong, Peoples R China

[4] HKUST Shenzhen Res Inst, South Area, Shenzhen 518057, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 25期

关键词：

FLUORESCENT-PROBE; PLASMA HOMOCYSTEINE; RISK-FACTOR; HYPERHOMOCYSTEINEMIA; DISEASE; RANGE;

D O I：

10.1039/c4tb00551a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Elevated levels of homocysteine (Hcy) in blood are indicative of many high risk cardiovascular and neurodegenerative diseases. Thus, development of highly efficient and selective dyes for monitoring Hcy levels has attracted much attention. This paper reports the utilization of TPE-Cy, an aggregation-induced-emission active hemicyanine dye, as a probe for the detection of Hcy. More interestingly, this dye shows high selectivity to Hcy over cysteine, glutathione and other amino acids in weakly basic buffer solution.

引用

页码：3919 / 3923

页数：5

共 38 条

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