Copper-catalyzed synthesis of aryl and alkyl trifluoromethyl sulfides using CF3SiMe3 and Na2S2O3 as -SCF3 source

被引：29

作者：

Zhong, Wei ^{[1
,2
]}

Liu, Xiaoming ^{[1
]}

机构：

[1] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 35期

基金：

中国国家自然科学基金;

关键词：

Trifluoromethylthiolation; Copper catalysis; Trifluoromethylthio group; One-pot reaction; HYPERVALENT IODINE REAGENT; OXIDATIVE TRIFLUOROMETHYLTHIOLATION; BORONIC ACIDS; ELECTROPHILIC TRIFLUOROMETHANESULFANYLATION; FLUOROALKYL SULFIDES; GRIGNARD-REAGENTS; FLUORINE; SALTS;

D O I：

10.1016/j.tetlet.2014.07.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A universal and efficient Cu(I)-catalyzed synthesis of aryl and alkyl trifluoromethyl sulfides has been developed. In this catalytic system, S-aryl or S-alkyl sulfothioate (I or II) proved to be the key intermediate. Substrates bearing groups of I, Br, Cl, OTs, and OMs on the aryl carbon and no matter electron-withdrawing and electron-donating substitutions on the aromatic ring could afford good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4909 / 4911

页数：3

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