Cancer-associated fibroblasts an their influence on tumor immunity and immunotherapy

被引：226

作者：

Barrett, Richard Lee ^{[1
]}

Pure, Ellen ^{[1
]}

机构：

[1] Univ Penn, Philadelphia, PA 19104 USA

来源：

ELIFE | 2020年 / 9卷

关键词：

NATURAL-KILLER-CELLS; ACTIVATION PROTEIN; TGF-BETA; EXTRACELLULAR-MATRIX; BREAST-CANCER; T-CELLS; ANTITUMOR IMMUNITY; SUPPRESSOR-CELLS; STROMAL CELLS; ANTIANGIOGENIC THERAPY;

D O I：

10.7554/eLife.57243

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture and function. Growth in most solid tumors is dependent upon remodeling 'stroma', composed of cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM), which plays a critical role in tumor initiation, progression, metastasis, and therapeutic resistance. Recent studies have clearly established that the potent immunosuppressive activity of stroma is a major mechanism by which stroma can promote tumor progression and confer resistance to immune-based therapies. Herein, we review recent advances in identifying the stroma-dependent mechanisms that regulate cancer-associated inflammation and antitumor immunity, in particular, the interactions between fibroblasts and immune cells. We also review the potential mechanisms by which stroma can confer resistance to immune-based therapies for solid tumors and current advancements in stroma-targeted therapies.

引用

页数：20

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