MEDPED and the Spanish familial hypercholesterolemia foundation

被引：11

作者：

Mata, P ^{[1
]}

Alonso, R

Castillo, S

Pocovi, M

机构：

[1] Fdn Jimenez Diaz, Unidad Lipidos, E-28040 Madrid, Spain

[2] Univ Zaragoza, Dept Bioquim Biol Mol & Celular, E-50009 Zaragoza, Spain

来源：

ATHEROSCLEROSIS SUPPLEMENTS | 2002年 / 2卷 / 03期

关键词：

familial hypercholesterolemia; cardiovascular disease; LDL-receptor gene;

D O I：

10.1016/S1567-5688(01)00014-9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We analysed clinical and genetic data of 819 non-related familial hypercholesterolemia patients. No differences on baseline low density lipoprotein (LDL) cholesterol levels between females and males were observed. High density lipoprotein (HDL) cholesterol values were higher in females than in males (57 +/- 15 vs. 47.7 +/- 13, respectively, P < 0.01). Premature cardiovascular disease was present in 21.7% of cases (30.8% in males and 14.3% in females, P < 0.001). A significant and positive correlation was observed between cardiovascular disease and age, gender, tobacco, total and LDL cholesterol levels at diagnosis, and negatively with HDL cholesterol levels. Analysis of LDL-receptor gene have been performed in 350 cases and 86 different mutations have been found. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：9 / 11

页数：3