Upregulated expression of human alpha-defensins 1, 2 and 3 in hypercholesteremia and its relationship with serum lipid levels

被引：8
作者：
Li, Yun-Xi [1 ]
Lin, Chao-Qun [1 ]
Shi, Da-Yu [2 ]
Zeng, Shu-Ying [1 ]
Li, Wen-Sheng [3 ]
机构：
[1] Southern Med Univ, Peoples Hosp Shunde 1, Dept Lab, Foshan 528300, Peoples R China
[2] Southern Med Univ, Peoples Hosp Shunde 1, Dept Pathol, Foshan 528300, Peoples R China
[3] Southern Med Univ, Peoples Hosp Shunde 1, Dept Cardiol, Foshan 528300, Peoples R China
来源：
HUMAN IMMUNOLOGY | 2014年 / 75卷 / 11期
关键词：
Human neutrophil peptide; Defensin; Gene expression; Hypercholesteremia; LOW-DENSITY-LIPOPROTEIN; PROTEIN-KINASE-C; DIFFERENTIAL EXPRESSION; ANTIMICROBIAL PEPTIDES; APOLIPOPROTEIN; CHOLESTEROL; NEUTROPHILS; RECEPTOR; RELEASE; PLASMA;
D O I：
10.1016/j.humimm.2014.09.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human alpha-defensins are natural antimicrobial peptides of neutrophils evolved in host defense reactions and circulating nonstressed alpha-defensins may be associated with serum lipid levels. The aim of this work was to examine whether the expression of alpha-defensins 1, 2 and 3 genes are changed and whether this changes are reversed following treatment in patients with hypercholesteremia. A total of 40 individuals of hypercholesteremia group were studied, compared with 40 individuals of normal control group. Protein levels and gene expression levels of alpha-defensins 1,2 and 3 were significantly higher in patients with hypercholesteremia compared with subjects in normal control group. In patients with hypercholesteremia, protein levels of alpha-defensins 1,2 and 3 correlated positively with the levels of total cholesterol and low-density lipoprotein cholesterol. Protein levels and gene expression levels of alpha-defensins 1, 2 and 3 were decreased significantly after a treatment with atorvastatin calcium 20 mg daily compared with the patients before the treatment. Our results suggest that the expression of alpha-defensins 1, 2 and 3 genes is involved in dyslipidemia in patients with hypercholesteremia. (C) 2014 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
引用
收藏
页码：1104 / 1109
页数：6
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