Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

被引：21

作者：

Bogolubsky, Andrey V. ^{[1
]}

Moroz, Yurii S. ^{[1
,2
]}

Mykhailiuk, Pavel K. ^{[1
,3
]}

Granat, Dmitry S. ^{[1
,3
]}

Pipko, Sergey E. ^{[2
]}

Konovets, Anzhelika I. ^{[1
,4
]}

Doroschuk, Roman ^{[3
]}

Tomachev, Andrey ^{[1
,2
]}

机构：

[1] Enamine Ltd, UA-01103 Kiev, Ukraine

[2] Kyiv Natl Taras Shevchenko Univ, ChemBioCtr, UA-02094 Kiev, Ukraine

[3] Kyiv Natl Taras Shevchenko Univ, Dept Chem, UA-01601 Kiev, Ukraine

[4] Kyiv Natl Taras Shevchenko Univ, Inst High Technol, UA-03187 Kiev, Ukraine

来源：

ACS COMBINATORIAL SCIENCE | 2014年 / 16卷 / 06期

关键词：

bis(2,2,2-trifluoroethyl)carbonate; functionalized amines; unsymmetrical aliphatic ureas; one-pot approach; parallel synthesis; AMINES; ACCESS;

D O I：

10.1021/co500025f

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of 96 diverse ureas was easily synthesized.

引用

页码：303 / 308

页数：6

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