Generation of novel DNA-binding compounds by selection and amplification from self-assembled combinatorial libraries

被引：83

作者：

Klekota, B ^{[1
]}

Hammond, MH ^{[1
]}

Miller, BL ^{[1
]}

机构：

[1] UNIV ROCHESTER,DEPT CHEM,ROCHESTER,NY 14627

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 50期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)10374-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a general method for the selection of compounds from self-assembled libraries which employs an immobilized receptor (i.e., an affinity reagent) to effect the selection. Using commercially available oligo d(A.T) DNA-cellulose resin, a set of three setereoisomeric coordination complexes are identified as DNA binding compounds from an equilibrating, self-assembled library of 36 bis(salicylaldiminato)-zinc coordination complexes. (C) 1997 Elsevier Science Ltd.

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收藏

页码：8639 / 8642

页数：4

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