Narrowband Magnetic Particle Imaging

被引：100

作者：

Goodwill, Patrick W. ^{[1
]}

Scott, Greig C. ^{[2
]}

Stang, Pascal P. ^{[2
]}

Conolly, Steven M. ^{[3
]}

机构：

[1] Univ Calif Berkeley, Berkeley Joint Grad Grp Bioengn, UCSF, Berkeley, CA 94720 USA

[2] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[3] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

来源：

IEEE TRANSACTIONS ON MEDICAL IMAGING | 2009年 / 28卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Angiography; inflammation tracking; intermodulation; magnetic nanoparticle imaging; magnetic particle imaging; narrowband; super-paramagnetic iron oxide (SPIO); CELLS; ACQUISITION;

D O I：

10.1109/TMI.2009.2013849

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

The magnetic particle imaging (MPI) method directly images the magnetization of super-paramagnetic iron oxide (SPIO) nanoparticles, which are contrast agents commonly used in magnetic resonance imaging (MRI). MPI, as originally envisioned, requires a high-bandwidth receiver coil and preamplifier, which are difficult to optimally noise match. This paper introduces Narrow-band MPI, which dramatically reduces bandwidth requirements and increases the signal-to-noise ratio for a fixed specific absorption rate. We employ a two-tone excitation (called intermodulation) that can be tailored for a high-Q, narrowband receiver coil. We then demonstrate a new MPI instrument capable of full 3-D tomographic imaging of SPIO particles by imaging acrylic and tissue phantoms.

引用

页码：1231 / 1237

页数：7

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